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EC number: 435-080-1 | CAS number: 1070-64-0 6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22. Sept 1998 to 13. Oct 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
- Specific details on test material used for the study:
- Batch: Ds02-01
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 2000mg/kg
- No. of animals per sex per dose:
- 7 animals per sex and dose
- Control animals:
- no
- Preliminary study:
- one animal per sex were given 200mg/kg and 1000mg/kg and 2000mg/kg. No deaths observed.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- one of 10 animals
- Gross pathology:
- all animals were normal at teh post mortem examination
- Other findings:
- Sedation and distrubed locomotion; Increased salivation and lacrimation and piloerection.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.
- Executive summary:
All males and 4/5 females survived until the scheduled termination of the study. One female died on the day of application. No cause of death could be identified.
Body weight and body weight gain of the surviving animals were inconspicuous
All animals were affected by piloerection, increased lacrimation and salivation. this is interpreted as autonomous nervous system effects
Disturbed locomotion , sedation, unconsciousness an righting reflex catalepsy indicate central nervous effects
The signs were observed on the day of the administration of the test substance and lasted until a maximum of 1 d p.a. No toxic effects were noted at later times. The same effects were observed in both esxes.
The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- one study prepared accoding to guideline is available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Not study necessary for tonnage band 1-10t
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8. Feb 2000 to 29. Feb 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Batch: Ds 1099
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Preliminary study:
- Range finding with 3 animals of each sex:
Dose: 400/894/2000 mg/kg --> all animals survived - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 000
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- other: not substance related
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.
No mortality occurred.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex. - Executive summary:
No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.
No mortality occurred.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- one study prepared accoding to guideline is available
Additional information
Justification for classification or non-classification
Studys according to guideline have been prepared for oral and dermal administration. No deaths occured at the highes dose. Therefore no classification is necessary.
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