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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions; no necropsy performed; no data about doses used; no mortality data available.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range finding toxicity data: List VI.
Author:
Smyth H.F. et al.:
Year:
1962
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 23: 95
Reference Type:
publication
Title:
Range finding toxicity data: List VII.
Author:
Smyth H.F. et al.
Year:
1969
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 30: 470-476

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method is described in the publication of Smyth et al (cf. Reference)
Gastric intubation of groups of 5 non-fasted male Carworth-Wistar rats (age: 4-5 weeks; bw: 90-120 g). The dosages were arranged in a logarithmic series differing by a factor of two. 14 days post-exposure observation period. No further details.
GLP compliance:
not specified
Test type:
other: Smyth and Carpenter (see reference)
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclopentene
EC Number:
205-532-9
EC Name:
Cyclopentene
Cas Number:
142-29-0
Molecular formula:
C5H8
IUPAC Name:
cyclopentene
Details on test material:
no further data available
Specific details on test material used for the study:
Not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Not specified
Doses:
1656.0 mg/kg bw (Original value 2.14 ml/kg (density cyclopentene 0.774 g/ml);
As no information about the number of administered dose levels is given, the total amount of animals could not be determined.
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Experimental methods remained unchanged and are described in the 1962 publication.
Statistics:
Not specified

Results and discussion

Preliminary study:
Not applicable
Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Remarks:
Single oral LD50
Effect level:
ca. 1 656 mg/kg bw
Based on:
test mat.
Mortality:
4/6 rats died following a 4-hour exposure to cyclopentene at 4000 rpm (inhalation of metered vapour concentration)
Clinical signs:
other: Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008
Conclusions:
Based on the results of the study, cyclopentene had a single dose LD50 in rats of 1656 mg/kg.
Executive summary:

A range-finding toxicity study was conducted with Wistar rats using a variety of substances, including the test substance, cyclopentene. The test substance was administered to Wistar rats as a single oral LD50 dose via oral gavage. Cyclopentene was shown to have a single dose LD50 in rats of 1656 mg/kg.