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Diss Factsheets
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EC number: 944-119-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in compliance with international recognized guidelines
- Justification for type of information:
- For Weight-of-Evidence Justification please refer to justification documentation in IUCLID Chapter 13.
Cross-reference
- Reason / purpose for cross-reference:
- assessment report
- Remarks:
- Justification for Weight-of-Evidence approach
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tin dioxide
- EC Number:
- 242-159-0
- EC Name:
- Tin dioxide
- Cas Number:
- 18282-10-5
- Molecular formula:
- O2 Sn
- IUPAC Name:
- Tin dioxide
- Details on test material:
- Name of the test item as cited in the report: Tin (IV) oxide extra pure
Appaerance: Whitish powder with a gray tinge.
Purity: 100.3%
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The water solubility of tin (IV) oxide is described to be very low and depending on temperature and pressure ( see point 4.8, The solubility of tin from tin dioxide in double distilled water at 20°C is below the limit of quantification (2.5 µl)) therefore no analysis was scheduled.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus)
Age: Daphnia magna, not older than 24 hours.
The strain with the parent generation was bred and maintained in vessels containing a batch of Daphnia magna of different ages.
Preparing a new study, juvenile Daphnia magna were separated and placed in 100 ml of reconstituted water. The water was renewed and the Daphni magna were fed with a suspension of fresh water algae once a week.
Newborn animals were separated and allocated to the different dose groups.
The Daphnia magna were kept in reconstituted water in glass vessels. The study was located in an air-conditioned room in the Institute of Toxicology
Lighting was controlled by a timer to provide a 16 hours light - 8 hours dark regime.
Temperature and humidity in the experimental room were measured using a thermohygrograph.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not applicable
Test conditions
- Hardness:
- 250 mg/L expressed as CaCO3
- Test temperature:
- During the experimental part, the temperature was registered in a control vessel with an electronic thermometer containing a maximum and minimum memory display: 22°C
- pH:
- The pH-values were measured in the control and all test material concentrations at the beginning and at the end of the experimental part.
7.9 ± 0.3 - Dissolved oxygen:
- The dissolved oxygen concentration (02) were measured in the control and all test material concentrations at the beginning and at the end of the experimental part.
Start of the experimental part (t=0): 97.8% ( control) and 94.4% (test item)
End of the experimental part: 96.8% (control) and 95.9% (test item) - Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentration: 0.1 g/L
- Details on test conditions:
- The test medium (reconstituted water and test material) was freshly prepared. Therefore, the calibrated flask with test material and vehicle, reconstituted water, was treated in an ultrasonic device for 1 hour. Subsequently the preparation was aerated, and stirred with a magnetic stirrer for further 23 hours. After 24 hours the preparation was given through a nutsch filter (pore size >10 - <16µm). The filtrate of the test material preparation was used for the study.
20 daphnia magna were used per test material concentration and 20 per control. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.1 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.1 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.1 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- In the control and in an aqueous solution of the test material concentration of nominal 0.1 g/L (limit test), no immobilized test animals were observed during the test period of 48 hours in a static open test system.
No remarkable observations were made concerning the appearance of the solution of the test material preparation. The test medium was a clear preparation and stayed unchanged throughout the study. - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the given experimental conditions, the test material (Tin (IV) oxide) showed a nominal 24 h and 48 h EC50 value> 0.1 g/L. Thus the EC50 of Tin dioxide exceeds the water solubility.
The no effect concentration for Daphnia magna was 0.1 g/L.
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