Registration Dossier
Registration Dossier
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EC number: 304-059-6 | CAS number: 94233-27-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- According to hydrolysis test results, the hydrolysis rate is estimated to be within several minutes. The hydrolysis products have been identified to be 2-ethylhexnol, acetylacetone and titanium dioxide. The sensitsation effect of those organic parts have been well-investigated separately.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
2-Ethylhexanol
There were no indications of sensitising action in workers of an EH production site (BGChemie, 1995). EH was tested for sensitisation in 29 subjects in a study by Opdyke (1979), according to the method of Kligman. Skin areas were pretreated with 5% sodium lauryl sulphate for 24 h. The induction was then performed four times for 28 h each with a cotton cloth soaked in a 4% solution of EH in paraffin oil. The challenge was performed with 4% EH for 48 h. None of the subjects showed any allergic reactions.
Pentane-2,4-dione
There is no reliable existing studies on 2,4-PD regarding sensitization. One reliable study indicated not sensitizing (Disseminated dossier, Source: European Chemicals Agency, http: //echa. europa. eu/)
Based on these findings, the target substance was considered not skin sensitizing.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The target substance is not classified as skin sensitizer according to CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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