Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance

Adequacy of study:

key study

Justification for type of information:

Please refer to the Analogue Justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

WAF

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 647028-25-9, Croda, 2000, O.mykiss, RL2

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 84418-63-3, Croda, 1993, O. mykiss, RL2

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 84418-63-3, Croda, 1993, O. mykiss, RL2

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 4.8 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura Corporation, 2012, Cyprinus carpio, RL1

Duration:

96 h

Dose descriptor:

LL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

other:

Remarks:

test mat. WAF

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura Corporation, 2012, Cyprinus carpio, RL1

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

4.8 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura Corporation, 2012, Cyprinus carpio, RL1

Duration:

96 h

Dose descriptor:

NOELR

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

other:

Remarks:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura Corporation, 2012, Cyprinus carpio, RL1

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 150 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 71010-76-9, Exxon, 2009, B.rerio, RL2

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.704 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

source, CAS 71010-76-9, Exxon, 2009, B.rerio, RL2

Description of key information

No effects up to the highest concentration tested; read-across.

Additional information

No study investigating the short-term toxicity of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids to freshwater fish is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3), Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2), Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representative for the evaluation of the short-term toxicity of the target substance to fish. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The first study investigated the acute toxicity effects of the source substance Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) to freshwater fish according to OECD guideline 203. The test was conducted as a limit test with rainbow trout (Oncorhynchus mykiss) as test organisms. The study was set up in a semi-static test system. Fish were exposed to the water accommodated fraction (WAF) of the test substance. At test termination after 96 h a LL50 >100 mg/L based on nominal loading rate was determined.
The study with source substance Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) was conducted under semi-static conditions equivalent to OECD guideline 203 with the rainbow trout. The test substance was directly added to the test vessel to prepare a test solution of nominal 1000 mg/L (limit test). No effects were observed after an exposure of 96 h resulting in a LC50 > 1000 mg/L.
The short-term toxicity of the source substance Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2) to freshwater fish was investigated according to OECD 203 under static conditions using Cyprinus carpio as test organism. A nominal loading rate of 100 mg/L (prepared as WAF) was applied. A test substance concentration of 4.8 mg/L was measured by chemical analysis. The 96 h-LL50 is determined to be > 100 mg/L (nominal) and > 4.8 mg/L (measured) and thus above the limit of water solubility.
Short-term toxicity of the source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) to freshwater fish was investigated according to OECD 203 under static conditions using Brachydanio rerioas test organism. Nominal test concentrations of 100 and 150 mg/L were applied corresponding to a measured test concentrations of 0.696 and 0.704 mg/L, respectively. The 96 h-LC50 is determined to be > 0.704 mg/L (arithmetic mean). No effects within the limit of water solubility (1.5 - 5.1 mg/L) are expected.

Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids will not result in toxicity up to the limit of water solubility.