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EC number: 279-510-2 | CAS number: 80584-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-10-19 to 2017-02-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 28.8 - 38.7 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: See remarks
- Remarks:
- As solubility was dependent on nominal concentration, no exact value for the solubility of the test item in water can be stated. The solubility range for the tested nominal concentration 1002 to 10002 mg/L is 28.8 to 38.7 mg/L at 20.0 ± 0.5°C. The mean value was stated as 33.3 ± 4.3 mg/L. Dependency of pH value on amount of the test item (nominal load) was not perceived.
- Details on results:
- As solubility of the test item in water was dependent on nominal concentration, the solubility range was stated
The higher the nominal load of the test item the lower is the dissolved part
Dependency of pH value on amount of the test item (nominal load) was not perceived - Conclusions:
- Interpretation of results: Slightly soluble (0.1-100 mg/L)
In conclusion, the water solubility of the test item VOELOFA Monomer was determined by the "flask method". The results demonstrate that the solubility of the test item in water was dependent on the nominal concentration (the higher the nominal load of the test item, the lower the dissolved part). The solubility range for the tested nominal concentration 1002 -10002 mg/L was stated as 28.8 - 38.7 mg/L at 20 °C. - Executive summary:
In this study the water solubility of VOELOFA Monomer was determined in accordance to OECD guideline 105. The solubility of the test item VOELOFA Monomer in water was determined by measurement of DOC concentration in the filtrated test solutions using TOC analyser. The main test was performed with six different loading rates. Dependency of solubility on the amount of test item (nominal load) was perceived. The solubility range for the tested nominal concentration 1002 -10002 mg/L was stated as 28.8 -38.7 mg/L at 20 °C. Thus, the mean value can be stated as 33.3 ± 4.3 mg/L. As dissolved carbon as a sum parameter for dissolved test item was measured, this study cannot distinguish between water solubility and hydrolysis of the test item.
Reference
Dependency of solubility on amount of the test item (nominal load) was perceived
Table 1: Measurements used for calculation of solubility |
||||
Flask |
Measurement conc. test item [mg/L] |
Nominal conc. test item [mg/L] |
Dissolved part [%] |
pH value |
2 |
28.82 |
1002 |
2.88 |
4.37 |
3 |
29.00 |
3009 |
0.96 |
4.63 |
4 |
34.11 |
6005 |
0.57 |
4.70 |
5 |
35.84 |
8002 |
0.45 |
4.73 |
6 |
38.66 |
10002 |
0.39 |
4.73 |
In a 10 mL centrifuge vial, 102.5 mg of the test item was weighed. In a stepwise procedure, increasing volumes of water were added, namely 0.1 mL, 0.5 mL, 1.0 mL, 2 mL and 10 mL (final volumes). After each addition of an amount of water, the mixture was shaken for 10 minutes and was visually checked for any undissolved parts of the sample. As undissolved particles were visible after addition of 10 mL H2O, the experiment was continued with 100.2 mg test item in 100 mL water in a Schott flask (concentration 1 g/L), but still no dissolution was observed, even after 10 minutes shaking.
Table 2: Preliminary study |
||||||
Added volume [mL] |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
Approx. solubility [g/L] |
> 1000 |
1000-200 |
200-100 |
100-50 |
50-10 |
10-1 |
Dissolution |
No |
No |
No |
No |
No |
No |
In order to determine the dependency of the water solubility on the amount of the test item added, six different loading rates were chosen in the range 1000 to 10000 mg/L (in the guideline the range 100 to 1000 mg/L is proposed). Higher range was used in this case because during the preliminary test, the measured concentration of DOC in 1 g/L of test item solution was in low calibration range (< 15 mg/L). Flask 1A was intended for the sampling point 24h, flask 1B for the sampling point 48h and flask 1C for the sampling points 72h. The following amounts were added to the flasks.
Table 3: Content of flasks |
|||
Flask no. |
Amount test item in mg |
Volume H2O in mL |
Resulting nominal concentration in mg/L |
1A |
500.3 |
100 |
5003 |
1B |
500.7 |
100 |
5007 |
1C |
500.4 |
100 |
5004 |
2 |
100.2 |
100 |
1002 |
3 |
300.9 |
100 |
3009 |
4 |
600.5 |
100 |
6005 |
5 |
800.2 |
100 |
8002 |
6 |
1000.2 |
100 |
10002 |
The data acquired during equilibration time (flask 1A-C, days 1-8) is presented in the following table:
Table 4: Data acquired during equilibration |
|||||
Day |
Temperature [°C] |
pH* |
Conc. DOC [mg/L] |
Conc. test item [mg/L] |
Difference to previous sample |
1 |
20.0 |
5-6 |
20.34 |
26.20 |
- |
2 |
20.0 |
5-6 |
20.67 |
26.63 |
+ 1.6% |
3 |
20.0 |
5-6 |
21.81 |
28.09 |
+ 5.5% |
6 |
20.0 |
5-6 |
51.14 |
65.88 |
+ 134.5% |
7 |
20.0 |
5-6 |
39.72 |
51.17 |
- 22.3% |
8 |
20.0 |
5-6 |
39.62 |
51.04 |
- 0.3% |
*measured via pH paper
The measurement value in the blank flask was below the LOQ of TC (< 1.10 mg/L). After the analysis of the sample of day 8, the plateau was considered as reached.
Table 5: Values measured at plateau in flasks 2-6 |
|||
Flask |
pH* |
Conc. DOC [mg/L] |
Conc. test item [mg/L] |
2 |
4.37 |
22.37 |
28.82 |
3 |
4.63 |
22.51 |
29.00 |
4 |
4.70 |
26.48 |
34.11 |
5 |
4.73 |
27.82 |
35.84 |
6 |
4.73 |
30.01 |
38.66 |
*measured via calibrated pH meter
The measurements on day 8 (flasks 2-6) were included in the calculation of the solubility of the test item in water. Flasks 1A-C were only used during equilibration.
Table 6: Measurements used for calculation of solubiltiy |
||||
Flask |
Measured conc. test item [mg/L] |
Nominal conc. test item [mg/L] |
Dissolved part [%] |
pH value |
2 |
28.82 |
1002 |
2.88 |
4.37 |
3 |
29.00 |
3009 |
0.96 |
4.63 |
4 |
34.11 |
6005 |
0.57 |
4.70 |
5 |
35.84 |
8002 |
0.45 |
4.73 |
6 |
38.66 |
10002 |
0.39 |
4.73 |
Description of key information
In this study the water solubility of VOELOFA Monomer was determined in accordance to OECD guideline 105. The solubility of the test item VOELOFA Monomer in water was determined by measurement of DOC concentration in the filtrated test solutions using TOC analyser. The main test was performed with six different loading rates. Dependency of solubility on the amount of test item (nominal load) was perceived. The solubility range for the tested nominal concentration 1002 -10002 mg/L was stated as 28.8 - 38.7 mg/L at 20 °C. Thus, the mean value can be stated as 33.3 ± 4.3 mg/L. Because dissolved carbon as a sum parameter for dissolved test item was measured, this study cannot distinguish between water solubility and hydrolysis of the test item.
Key value for chemical safety assessment
- Water solubility:
- 38.7 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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