Registration Dossier
Registration Dossier
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EC number: 221-218-4 | CAS number: 3033-29-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
By read-across to Dioctyltin oxide, the NOEC of Dioctyltin mercaptopropionate on the respiration of activated sewage sludge corrected for molecular weight is considered to be 1244 mg/L and thus greater than the water solubility, corrected for molecular weight the 3 h EC50 was > 1244 mg/L.
Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
The effect of DOTO on the respiration of activated sewage sludge gave a 3 hour EC50 value of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L. No statistically significant toxic effects were shown at any of the test concentrations employed. It was therefore considered justifiable not to perform a definitive test.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 244 mg/L
Additional information
Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
A range-finding study was performed to assess the effect of DOTO on the respiration of activated sewage sludge. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (2010) No. 209 "Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation) ".
Activated sewage sludge was exposed to an aqueous dispersion of DOTO at concentrations of 10, 100 and 1000 mg/L for a period of 3 hours at a temperature of 20 ± 2°C, with the addition of a synthetic sewage as a respiratory substrate.
The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol.
The effect of DOTO on the respiration of activated sewage sludge gave a 3 hour EC50 value of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L. No statistically significant toxic effects were shown at any of the test concentrations employed. It was therefore considered justifiable not to perform a definitive test.
Based on read-across to Dioctyltin oxide, corrected for molecular weight the 3 h EC50 was > 1244 mg/L.
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