Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-818-5 | CAS number: 100-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Fish: LC50 (96 h) > 100 mg/L (nominal, OECD 203,Oncorhynchus mykiss, read-across from sodium anisate CAS 536-45-8)
Aquatic invertebrates: EC50 (48 h) = 943 mg/L (nominal, similar to OECD 202, Daphnia magna)
Algae/aquatic plant: ErC50 (72 h) > 320 mg/L (nominal, OECD 201, Pseudokirchneriella subcapitata, read-across from sodium anisate CAS 536-45-8)
Algae/aquatic plant: ErC10 (72 h) > 320 mg/L (nominal, OECD 201, Pseudokirchneriella subcapitata, read-across from sodium anisate CAS 536-45-8)
Additional information
The acute toxicity of the test item to aquatic invertebrates was investigated in a study by Kamaya et al. (2005). Daphnia magna was exposed for 48 hours to the test material at nominal concentrations of 2 mmol/L (304.3 mg/L) to 12 mmol/L (1825.8 mg/L). Samples from all concentrations and the control were checked before and after (48 h) exposure experiments by the UV spectra (400–200 nm). The EC50 (48 h) was determined at 943 mg/L.
No data are available on the toxicity of p-anisic-acid (CAS No. 100-09-4) towards fish, aquatic algae, and microorganisms. Therefore, data from the analogue substance sodium anisate (CAS 536-45-8) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
Experimental studies for sodium anisate (CAS 536-45-8) are available investigating the short-term effects on fish, aquatic algae, and microorganisms. The studies were performed according to internationally accepted guidelines in accordance with GLP.
One experimental study is available investigating the toxicity of the substance to fish. The study was conducted according to OECD 203 and 126 (GLP) using the rainbow trout Oncorhynchus mykiss under semi-static conditions. The absence of mortality at 100 mg/L indicated that fish was not the most sensitive group of test organisms and that the LC50 is greater than the limit test concentration. The measured content of the test item in the fresh as well as in aged test solution was 106% of nominal. Since the content of active ingredient in the samples was between 80 and 120% of nominal, the toxicological endpoints were evaluated using nominal test item concentrations. The LC50 (96 h) of the test item was determined to be > 100 mg/L test item (nominal). The corresponding NOEC (mortality) (96 h) was 100 mg/L test item (nominal). No sublethal effects were observed in the control and test item concentration 100 mg/L after 96 h.
One experimental study is available investigating the toxicity of the substance to aquatic freshwater algae. The study was conducted according to OECD 201 (GLP) using the freshwater algae Pseudokirchneriella subcapitata. The definitive test was carried out with the following concentration range: control, 3.2, 10, 32, 100 and 320 mg test item/L (nominal). The measured concentrations of the test item at test start (0h) and test end ranged between 90% and 109% of the nominal values. Thus, it is justified that the effect concentrations are based on the nominal concentrations. Inhibition of growth was recorded resulting in an ErC10 and ErC50 (72h) of >320 mg/L. Inhibition of yield was recorded resulting in an EyC10 of 115 mg/L and EyC50 (72 h) of >320 mg/L.
To cover the endpoint toxicity to microorganisms a biodegradation test according to OECD guideline 301F is available. The test includes a toxicity control, which contains 102.7 mg/L of the test item and 104.1 mg/L mg/L of sodium benzoate. The toxicity control attained 30% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 102.7 mg/L can be used as NOEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.