Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-1 (Fish Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 24088
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable at room temperature
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in water
- Final dilution of a dissolved solid, stock liquid or gel: 0.10, 0.18, 0.28, 0.41 and 0.70 mg/L
OTHER SPECIFICS: Purity of test material was 14.17% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0.10, 0.18, 0.28, 0.41 and 0.70 mg CMIT/MIT per liter
- Sampling method: Samples were collected from each test vessel at the initiation of the test and from 1 replicate of each concentration at the conclusion of the test. The samples were stored in 40 mL glass bottles and transferred immediately to the analytical laboratory.
- Sample storage conditions before analysis: Stored at 2-4 ºC for 96 hours or less prior to analysis - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Mixing
- Controls: Negative control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Water
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): Not applicable
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): No - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Aquatic Research Organisms division of Resource Analysts, Inc.
- Age at study initiation (mean and range, SD): Juvenile fish
- Length at study initiation (length definition, mean, range and SD): 30.5 mm
- Weight at study initiation (mean and range, SD): 0.52 g
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions (same as test or not): Yes
- Type and amount of food during acclimation: Commercial dry food, ad libitum
- Feeding frequency during acclimation: Daily
- Health during acclimation (any mortality observed): Not described
FEEDING DURING TEST
Not applicable - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- n/a
- Post exposure observation period:
- n/a
- Hardness:
- 40-44 mg/L (as CaCO3)
- Test temperature:
- 11.5-12.8°C (0h), 11.6-12.1°C (48h) and11.8-12.7°C (96h)
- pH:
- 8.0 (0h), 7.8-7.9 (48h) and 8.2 (96h)
- Dissolved oxygen:
- 10.2-10.4 mg/L (0h), 10.4 mg/L (48h) and 10.4-10.6 mg/L (96h)
- Salinity:
- Not applicable
- Conductivity:
- Not described
- Nominal and measured concentrations:
- Nominal (mg CMIT / MIT per liter):0.10, 0.18, 0.28, 0.41 and 0.70
Measured concentrations (mg CMIT/MIT per liter): 0.13, 0.20, 0.31, 0.45 and 0.71 - Details on test conditions:
- TEST SYSTEM
- Test vessel: Flow-through
-Renewal of test solution: An intermittent flow proportional diluter supplied the test substance to the test vessels. During the test the diluter was activated 773 times, resulting in an average of 6.4 media exchanges per 24 hours in each test vessel.
- Volume of vessel: 19.6 L test aquaria
-Volume/animal: 1.96 L
-Number of vessels/ concentration: 2
-Number of animals/vessel: 10
-Test performed in closed vessels due to significant volatility of TS: No
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: EnviroSystems well water
- Alkalinity: 100-110 mg/L
OTHER TEST CONDITIONS
- Adjustment of pH: No. pH range was variation measured during the conduct of the study.
- Photoperiod: 16 h daylight, 8 h dark
- Light intensity: Cool white fluorescent lights with intensity of 10 µEs-1m-2 - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.19 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.13 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: One fish exposed to 0.20 mg CMIT/MIT/L exhibited loss of equilibrium and was gasping at the surface after 72 hours. One fish exhibited loss of equilibrium and erratic swimming after 96 hours.
- Observations on body length and weight: No effects
- Other biological observations: No
- Mortality of control: 5% (1 of 20 fish)
- Other adverse effects control: No
- Abnormal responses: No
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No
- Effect concentrations exceeding solubility of substance in test medium: No - Reported statistics and error estimates:
- The binomial method was used to calculate the 24, 48, 72 and 96 hour median lethal concentrations (LC50s). All calculations were performed using computer methods (Stephan C.E., 1983, Computer program for the calculation of LC50 Values, US EPA, Duluth, Minnesota, USA, Personal communication) and mean measured concentrations of the active ingredient.
- Sublethal observations / clinical signs:
Mortality data
Test Substance
Concentration
(mean measured)[mg CMIT/MIT per liter]
Mortality
Number
24 h 48 h 72 h 96 h
Percentage
24 h 48 h 72 h 96 h
0 (water control)
0/20
1/20
1/20
1/20
0
5
5
5
0.13
0/20
0/20
0/20
0/20
0
0
0
0
0.20
1/20
5/20
8/20
11/20
5
25
40
55
0.31
20/20
20/20
20/20
20/20
100
100
100
100
0.45
20/20
20/20
20/20
20/20
100
100
100
100
0.71
20/20
20/20
20/20
20/20
100
100
100
100
Temperature [°C]
12.2-12.9
11.6-12.1
11.5-12.0
11.8-12.7
pH
8.1-8.2
7.8-7.9
8.2
8.2
Oxygen [mg/L]
10.6-10.9
10.4
10.4-11.0
10.4-10.6
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h LC50 of CMIT/MIT to rainbow trout was determined to be 0.19 mg/L.
- Executive summary:
- US EPA Guideline 72-1, Acute flow-through 96 h fish study with analytical confirmation of test solution concentrations. At the end of the test, the mortality in the controls does not exceed 10%: one fish in twenty was found immobile in the water controls. Constant conditions are maintained throughout the test. The dissolved oxygen concentration has been at least 60% of the ASV throughout the test. The results were based on mean measured concentrations: 96h NOEC = 0.13 mg a.s./l; 96h LC50= 0.19 mg a.s./l.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Test substance was not analytically determined in the testing solutions
- Qualifier:
- according to guideline
- Guideline:
- other: American Society for Testing and Materials Committee E-35 on Pesticides, 1980, Standard practice for conducting basic acute toxicity tests with fishes, macro-invertebrates and amphibians.
- Deviations:
- yes
- Remarks:
- The test substance was not analytically determined in the testing solutions.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. TD80-50
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable at room temperature
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in water
- Final dilution of a dissolved solid, stock liquid or gel: 0.18, 0.31, 0.50, 0.83, and 1.39 ppm
OTHER SPECIFICS: Purity of test material was 13.9% - Analytical monitoring:
- no
- Details on sampling:
- n/a
- Vehicle:
- yes
- Details on test solutions:
- n/a
- Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheepshead minnow
- Source: Hatached and reared at Bionomics Marine Research Laboratory, Pensacola, Florida, USA.
- Age at study initiation (mean and range, SD): Juvenile fish
- Length at study initiation (length definition, mean, range and SD): 4-7 mm standard length.
- Weight at study initiation (mean and range, SD): 3-7 mg wet weight
FEEDING DURING TEST
Not applicable - Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- n/a
- Hardness:
- Not described
- Test temperature:
- 21 °C
- pH:
- 7.4 – 8.0
- Dissolved oxygen:
- 58 – 87 %
- Salinity:
- 22 ppt
- Conductivity:
- Not described
- Nominal and measured concentrations:
- Nominal (CMIT / MIT ppm or mg/liter) active substance: 0.18, 0.31, 0.50, 0.83, and 1.39 ppm
The test substance was not analytically determined in the testing solutions. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Static system
- Material, size, headspace, fill volume: 3.8 L glass jars
- Aeration: Yes
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Sea water pumped from Big Lagoon, a Gulf of Mexico estuary
- Alkalinity: 190-195 mg/L
- Culture medium different from test medium: No
OTHER TEST CONDITIONS
- Adjustment of pH: Not described
- Photoperiod: Not described
- Light intensity: Not described
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality at 24, 48, 72 and 96h - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: No effects
- Observations on body length and weight: No effects
- Other biological observations: No
- Mortality of control: 0%
- Other adverse effects control: No
- Abnormal responses: No
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: No - Reported statistics and error estimates:
- The binomial test for estimating LC50 was applied (Stephan, C.E. (1977) ‘Methods for Calculating an LC50’, Aquatic Toxicology and Hazard Evaluation, ASTM STP 634, F.L. Mayer and J.L. Hamelink, Editors, pp. 65-84, American Society for Testing and Materials).
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of this study, CMIT/MIT is very toxic to aquatic organisms, with a 96-h LC50 of 0.30 mg/L.
- Executive summary:
This study was conducted in compliance with: American Society for Testing and Materials Committee E-35 on Pesticides, 1980, Standard practice for conducting basic acute toxicity tests with fishes, macroinverrtebrates and amphibians, acute 96-hour static marine fish study. At the end of the test, the mortality in the controls does not exceed 10%: any fish in twenty is found immobile in the water controls. Constant conditions are maintained throughout the test. The dissolved oxygen concentration has been at least 60% of the ASV throughout the test. As the test substance concentrations are not analyzed, theresults are based on nominal concentrations: 96h NOEC = 0.18 mg a.s./l; 96h LC50= 0.30 mg a.s./l.
Referenceopen allclose all
Description of key information
The results of the key study indicated that exposure of the rainbow trout to CMIT/MIT resulted
in a 96-hour median lethal concentration (LC50) of 0.19 mg a.i./L.Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.19 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0.3 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.