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EC number: 276-012-7 | CAS number: 71786-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Copper, [[[[3-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]phenyl]amino]sulfonyl]-29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, aminosulfonyl sulfo derivs., sodium salts
- EC Number:
- 276-012-7
- EC Name:
- Copper, [[[[3-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]phenyl]amino]sulfonyl]-29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, aminosulfonyl sulfo derivs., sodium salts
- Cas Number:
- 71786-55-5
- Molecular formula:
- cannot be displayed for UVCB
- IUPAC Name:
- Copper, ((((3-((5-chloro-2,6-difluoro-4-pyrimidinyl)amino)phenyl)amino)sulfonyl)-29H,31Hphthalocyaninato (2-)-kappaN29,kappaN30,kappaN31,kappaN32)-, aminosulfonyl sulfo derivs., sodium salts
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Han-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: KFM, CH-4414 Fullinsdorf, Switzerland
- Weight at study initiation: 160-185 g
- Fasting period before study: 18 hours
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: five days prior to the start of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2 °C
- Humidity (%): 30%-70%
- Air changes (per hr): 15 changes/hour
- Photoperiod (hrs dark / hrs light): Light/dark cycle was 12 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: WEM
- No. of animals per sex per dose:
- Five males and five females
- Details on study design:
- - Duration of observation period following administration: 14 days after dosing
- Frequency of observations and weighing: Observation once in the morning and once in the late afternoon, weighing on day 1, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, approximate time of death, the nature, severity, approximate time of onset and duration of each toxic sign
Results and discussion
- Preliminary study:
- A preliminary study was carried out to establish a dosing regimen, using groups of two males and two females at one dosage, using 20 ml/Kg body weight
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0
- Clinical signs:
- other: The animals were weak, flaccid and showed a rough coat
Any other information on results incl. tables
Results of the main study
Sex |
Dosage |
Body weight (g) at |
Mortality ratio |
Time of death after dos. (hours) |
||
Dosing |
1 week |
2 weeks |
||||
M |
5000 |
179 |
232 |
269 |
0/5 |
- |
F |
5000 |
173 |
196 |
202 |
0/5 |
- |
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Conclusions:
- The test substance is acute oral practically non toxic.
LD50 > 5000 mg/kg - Executive summary:
The study was carried out in accordance with OECD Guideline No. 401, "Acute Oral Toxicity".
The substance was administered by oral gavage, to five rats of each sex, at 5000 mg/kg body weight. Macroscopic examination was performed at the end of the experìmental period. Apart from pìloerection, and dark blue urine and faeces noted, no signs of ill health or behaviour changes were seen during the observation period. Macroscopic post mortem examination of the surviving animals at termination revealed greenish discolouration of the glandular stomach, intestines and mesenterial lymph nodes, dark red / black coloured kidneys in all animals, and thickening of the limiting ridge and greenish discolouration of the testes in a few ani ma'ls. The oral LD50 value in rats of either sex was established as exceeding 5000 mg/kg body weight.
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