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Diss Factsheets
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EC number: 205-521-9 | CAS number: 142-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, no analytical monitoring
- Principles of method if other than guideline:
- toxicity testing to Tetrahymena pyriformis according to Schultz et al. (1997); TERATOX assay
A short-term, static protocol using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) is reported. The 50% impairment growth
concentration (IGC50) is the endpoint of choice. - GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- - Source: Test organisms was obtained from Jorgen Larsen, Environmental Technology, Danish Technological Insitute (P.O. Box 141, DK-2630, Taasturp, Denmark).
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 40 h
- Test temperature:
- 27 ±1 °C
- Details on test conditions:
- A short-term, static protocol using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) is reported. The 50% impairment growth
concentration (IGC50) is the endpoint of choice. Cultures are reared in 50 mL of a semidefined medium in 250 mL Erlenmeyer flasks. Definitive test
replicates consist of six to ten different concentrations of each test material with duplicate flasks. Duplicate flasks are inoculated to an initial density of approx. 2500 cells/mL with log-growth-phase ciliates. Following 40 h of incubation at 27 ±1 °C, population density is quantified
spectrophotometrically at 540 nm and 50% effect levels are determined by Probit Analysis of Statistical Analysis system software.
Toxicity was assessed in the 2-day Tetrahymena pyriformis (strain GL-C) population growth impairment assay. The test followed the protocol
described by Schultz (1997).
TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed (foam stoppered)
- Material, size, headspace, fill volume: 50 mL of a semidefined medium in 250 mL Erlenmeyer flasks
- No. of organisms per vessel: 2500 cells/mL
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 2 - Duration:
- 40 h
- Dose descriptor:
- other: IGC50
- Effect conc.:
- 13.93 mg/L
- Remarks on result:
- other: Original value: log(IGC50 E-1): 1.087 mM
- Conclusions:
- In a short-term, static study using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) the 50% impairment growth concentration (IGC50) is 19.93 mg/L.
- Executive summary:
In a short-term, static study using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) the 50% impairment growth concentration (IGC50) is 19.93 mg/L.
Reference
Description of key information
In a short-term, static study using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) the 50% impairment growth concentration (IGC50) is 19.93 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 19.93 mg/L
Additional information
In a short-term, static study using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) the 50% impairment growth concentration (IGC50) is 19.93 mg/L.
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