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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
It was noted that the correlation between hydrogen ion concentration and time was stronger at 30 °C for each pH level tested, and the strongest correlation was found in pH 7. This information supports the preliminary observations indicating the material may undergo hydrolysis in water (OECD 111).
Key value for chemical safety assessment
Additional information
GUIDELINE
The investigation was performed in accordance with Organization for Economic Cooperation and Development (OECD) Guideline for the Testing of Chemicals. Hydrolysis as a Function of pH, OECD Guideline No. 111 (April 13, 2004).
METHODS
A preliminary test of test item stability in water was conducted during examination of water solubility and showed an increase of hydrogen ion concentration over time, which indicated possible hydrolysis. Additional testing was performed in sterile aqueous buffers prepared at pH 4, 7, and 9 at three temperatures (10, 20, and 30°C).
Test solutions were prepared in pH 4, 7, and 9 buffers at approximately 0.5 mg/mL by weighing 0.5 g into each of 3, 1-L autoclaved volumetric flasks and bringing to volume with the respective buffers.
Each dosing solution was distributed into an appropriate number of autoclaved 2-dram vials, which were filled leaving no headspace and sealed with PTFE lined caps. Subsets of vials for each pH were placed in temperature-controlled chambers set to maintain 10, 20, and 30°C. The pH of each remaining dosing solution was measured. Vials containing buffers with no test material were prepared in the same way as the samples to check for background contamination.
Sampling for pH 4 at all temperatures was performed after approximately 1, 2, 3, 4, 5, 6, 23, 29, 48, and 53 hours by removing two vials at random and measuring pH and temperature immediately. This process above was repeated for pH 7 and 9 after approximately 2, 4, 5, 23, 29, 48, and 53 hours.
Following completion of the test period, the vials containing each buffer which had been stored at 30°C were removed for sterility check. An aliquot (1 mL) of each buffer was applied to individual 3M petrifilm plates while contained in a biological safety cabinet. The plates were placed in an incubator set at 35 °C for approximately 48 hours before being removed and visually observed for the presence of colonies.
RESULTS
It was noted that the correlation between hydrogen ion concentration and time was stronger at 30 °C for each pH level tested, and the strongest correlation was found in pH 7. This information supports the preliminary observations indicating the material may undergo hydrolysis in water.
CONCLUSION
It was noted that the correlation between hydrogen ion concentration and time was stronger at 30 °C for each pH level tested, and the strongest correlation was found in pH 7. This information supports the preliminary observations indicating the material may undergo hydrolysis in water.
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