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Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 November 2012 to 5 April 2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The analytical method used is the determination of the total organic carbon (TOC), which is forseen for the determination of solution of polymers in water (EU Method A.20) but not listed among the "preferred method" for the datermination of the water solubility, due to their incapacity to differentiate between the main substance and the impurities. The results can be therefore considered as reliable with restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

flask method

Key result

Water solubility:

37.41 mg/L

Conc. based on:

element (dissolved fraction)

Remarks:

Dissolved organic carbon

Incubation duration:

6 d

Temp.:

30 °C

pH:

5.4

Elemental analysis

Sample name	C (wt%)	H (wt%)
Test substance	79.20	12.58

 

Total organic carbon in the blank test (deionized water)

Sample name	TOC (mg/L)	pH
blank	0.229	5.50

 

TOC content measurement after test

Shaking duration	Sample concentration [mg/L]	TOC [mg/L]	ΔTOC [mg/L]	Average ΔTOC [mg/L]
1 day	1000	16.28	16.06	15.94
		16.05	15.83
2 days	1000	24.69	24.46	24.14
		24.04	23.82
3 days	1000	28.29	28.06	28.03
		28.23	28.01
4 days	1000	29.37	29.14	29.37
		29.83	29.61
5 days	1000	29.27	29.05	29.15
		29.48	29.25
6 days	1000	30.27	30.05	29.63
		29.44	29.21

 

Water solubility and the pH change of samples after testing

Shaking duration	Shaking Temperature [°C]	Water solubility [mg/L]	pH after test
1 day	30	20.13	5.40
2 days	30	30.47	5.38
3 days	30	35.40	5.45
4 days	30	37.09	5.32
5 days	30	36.81	5.35
6 days	30	37.41	5.40

 

Conclusion

The water solubility of the test substance was determined by TOC (total organic carbon) after six days to be 37.41 mg/L at 20 °C and pH ca. 5.4.

Conclusions:

A water solubility value of 37.41 mg/L (at 20 °C, pH ca. 5.4) was determined for the test substance according to OECD guideline 105.

Description of key information

Water solubility: 37.41 mg/L at 20 °C, pH = 5.4 (OECD guideline 105, flask method)

Key value for chemical safety assessment

Water solubility:

37.41 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test substance was calculated based on the dissolved organic carbon concentration (DOC analysis).