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Diss Factsheets
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EC number: 253-197-2 | CAS number: 36768-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed prior to OECD guideline and GLP principles but follows principles thereof.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR 16, 4500.42
- Deviations:
- no
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- no
- Remarks:
- Study was perfomed prior to GLP settings
Test material
- Reference substance name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- EC Number:
- 253-197-2
- EC Name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- Cas Number:
- 36768-62-4
- Molecular formula:
- C9H20N2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-amine
- Details on test material:
- Name of test material (as cited in study report): Triacetondiamin
- Substance type: colourless liquid with low viscosity
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: J. Scheele, Büdrich/Westfalen, Werl, Germany
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
Temperature: 21-23°C
climated rooms
light circle dark/light: 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- Single instillation into the conjunctival sac; The test item was placed in the conjunctival sac of the right eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second in order to prevent loss of the material. The left eye, which remained untreated, served as a control. No rinsing was performed.
- Observation period (in vivo):
- Due to the observed effects all animals were killed after 24 h after application for human reasons
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM:
According to Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics published by the Food and Drug Officialy of the United States, 1959
TOOL USED TO ASSESS SCORE: no
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other: animals killed after 24 h for human reasons
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- > 2
- Max. score:
- 2
- Remarks on result:
- other: not assessable
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness and chemosis
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- > 4
- Max. score:
- 4
- Remarks on result:
- other: black discolouration
- Irritant / corrosive response data:
- total irritation could not be calculated. After 24 h, high-grade irritation associated with strong swelling and black-coloured necrosis of the conjunctivae as well as complete opacity of the corneas in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Six rabbits exposed for 24 hours to 0.1 mL test substance in the conjuncital sac revealed high-grade irritation associated with strong swelling and black-coloured necrosis of the conjunctivae as well as complete opacity of the corneas in all animals. Therefore, under conditions tested, the test substance is regarded to be corrosive.
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