Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature (handbook)

Data source

Reference
Reference Type:
review article or handbook
Title:
Patty's Industrial Hygiene and Toxicology
Author:
Rowe and McCollister
Year:
1982
Bibliographic source:
Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Evaluation of the skin irritation potential following repeated application (open, semiocclusive and occlusive) to rabbit skin.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylbutan-2-ol
EC Number:
200-908-9
EC Name:
2-methylbutan-2-ol
Cas Number:
75-85-4
Molecular formula:
C5H12O
IUPAC Name:
2-methylbutan-2-ol

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
other: open, semiocclusive and occlusive
Preparation of test site:
not specified
Vehicle:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
other: general skin irritation
Time point:
other: unknown
Reversibility:
no data
Remarks on result:
other: No scores reported, observations made following repeated application: no irritation (uncovered skin), redness and exfoliation (semiocclusive), severe necrosis (occlusive).
Irritant / corrosive response data:
When the test substance was applied repeatedly to the uncovered skin of the rabbit it did not cause irritation but if the skin was covered with a cloth, redness and exfoliation resulted. Confinement of the material under an impervious covering resulted in severe necrosis.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The skin irritation potential of the test item was determined. Skin irritating effects were observed.
Executive summary:

The skin irritation potential of the test item was determined. The test substance was applied repeatedly to the uncovered skin of the rabbit. The type of coverage was open, semiocclusive and occlusive. Skin irritating effects were observed. If the skin was covered with a cloth, redness and exfoliation were observed. Confinement of the material under an impervious covering resulted in severe necrosis. No scores were reported.