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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Company-internal protocol
Principles of method if other than guideline:
20h occlusive dermal exposure of 2 rabbits to 1g of moistened test substance on a cotton patch of 2.5 x 2.5 cm
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
EC Number:
304-661-9
EC Name:
Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
Cas Number:
94277-77-7
Molecular formula:
C65 H84 Cu N11 O12 S4 .C11 H25 N O .H
IUPAC Name:
copper(2+) hydrogen 3-[(2-ethylhexyl)oxy]propan-1-amine 14,24,32-tris({[({3-[(2-ethylhexyl)oxy]propyl}amino)oxy]sulfonyl})-2,11,20,29,37,38,39,40-octaazanonacyclo[28.6.1.1³,¹⁰.1¹²,¹⁹.1²¹,²⁸.0⁴,⁹.0¹³,¹⁸.0²²,²⁷.0³¹,³⁶]tetraconta-1,3(40),4,6,8,10,12,14,16,18,20,22,24,26,28(38),29,31,33,35-nonadecaene-37,39-diide-5-sulfonate
Details on test material:
Name in report: Cu-Phthalocyanin-sulfochlorid, umgesetzt mit 2-2-Aethylhexoxypropylamin
Substance type: solid, blue

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: purchased externally
- Weight at study initiation:2,87 kg and 3.17 kg

IN-LIFE DATES: From: 1972-03-27 To: 1972-04-04

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
ca. 1 g of a 50% aqueous test substance preparation
Duration of treatment / exposure:
20 hours
Observation period:
8 days
Number of animals:
2
Details on study design:
Application area: 2.5 x 2.5 cm
Application site: back
The test substance was not washed off.

Scoring for redness, oedema, scaring, scabbing, necrosis. (0 = no finding; then four categories "questionable", "mild", "strong", "severe")

Time points scored: After 20h, day 2, day 3, day 4 and day 8

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: both animals
Time point:
other: 20 h, days 2,3,4 and 8
Score:
0
Max. score:
4
Remarks on result:
other: blue test substance residues; inflammation may not have been visible.
Irritation parameter:
edema score
Basis:
other: both animals
Time point:
other: 20 h, days 2,3,4 and 8
Score:
0
Max. score:
4
Irritant / corrosive response data:
The animals did not show signs of inflammation.
Other effects:
Animal one had one lost 90g of weight from the beginning of treatment to the end of the observation period.
Animal two had gained 50g of weight from the beginning of treatment to the end of the observation period.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

20h occlusive exposure of shaved rabbit skin did not cause local effects other than bluish coloration by the blue substance.