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EC number: 231-634-8 | CAS number: 7664-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Recent published peer reviewed study
Data source
Reference
- Reference Type:
- publication
- Title:
- Harmful effects and acute lethal toxicity of intraveneous administration of low concentrations of hydrofluoric acid in rats
- Author:
- Mitsui G, Dote T, Adachi K, Dote E, Fujimoto K, Shimbo Y, Fujihara M, Shimizu H, Usuda K & Kono K
- Year:
- 2 007
- Bibliographic source:
- Toxicology and Industrial Health, 23: 5-12
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigation of acute toxicity using intravenous administration
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- Molecular formula:
- FH
- IUPAC Name:
- hydrogen fluoride
- Details on test material:
- Hydrofluoric acid (HFA: concentration 46%) obtained from Wako Pure Chemical Industries Ltd., Japan. The chemical was dissolved/diluted in saline.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Nine week old SPF male Sprague-Dawley rats, weighing 290-300 g. Rat chow (Funabashi Farm MM-3, Japan) and tap water were provided ad libitum. Temperature was maintained at 22±1°C under a 12 hour light/dark cycle.
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: saline
- Details on exposure:
- Lethal dose study: Rats were anaesthetised with pentobarbital. One of five HFA concentrations (0.3, 0.4, 0.5, 0.6 or 0.7%) was injected through the tail vein by a syringe pump for 1 minute. Total volume injected was 1 ml, and speed of injection was 1 ml/min.
Sublethal acute study: Rats were anaesthetised with pentobarbital. One of four HFA concentrations (0.05, 0.1, 0.2 or 0.3%) was injected through the tail vein by syringe pump. Saline was used as the control. Total volume injected was 1 ml, and speed of injection was 1 ml/min. - Doses:
- Lethal dose study: 9.9, 13.1, 16.4, 19.7 and 23.0 mg/kg bw
Sublethal acute study: 0, 1.6, 3.2, 6.4 and 9.6 mg/kg bw - No. of animals per sex per dose:
- 5 males per group
- Control animals:
- yes
- Details on study design:
- Blood samples were obtained from the carotid artery 1 hour after infusion. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), mitochondrial asparate aminotransferase (m-AST), lactate dehydrogenase (LDH), LDH isozyme and serum glucose were measured. Kidney function was determined according to blood urea nitrogen (BUN) and creatinine (Cr).
- Statistics:
- Probit analysis and ANOVA.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LCLo
- Effect level:
- 13.1 mg/kg bw
- Remarks on result:
- other: i.v.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 17.4 mg/kg bw
- Remarks on result:
- other: i.v.
- Sex:
- male
- Dose descriptor:
- other: LD90
- Effect level:
- 23 mg/kg bw
- Remarks on result:
- other: i.v.
- Mortality:
- 13.1 mg/kg resulted in the death of 2/5 rats.
- Clinical signs:
- Not reported
- Body weight:
- Not deterined
- Gross pathology:
- Not examined
- Other findings:
- BUN was slightly increased in the 1.6 mg/kg group, and was significantly increased in the 3.2, 6.4 and 9.6 mg/kg groups compared with the saline only group. Cr was slightly increased in the 1.6 mg/kg group, and significantly increased in the 3.2, 6.4 and 9.6 mg/kg groups. Serum glucose was significantly increased in the HFA group. There were no other changes in haematology parameters.
Any other information on results incl. tables
No further information
Applicant's summary and conclusion
- Conclusions:
- The i.v. LDLo was 13.1 mg/kg, and the i.v. LD50 was 17.4 mg/kg.
- Executive summary:
The acute toxicity of hydrofluoric acid was determined following intravenous infusion in anaesthetised rats. The i.v. LDLo was 13.1 mg/kg, and the i.v. LD50was 17.4 mg/kg.
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