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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented and scientifically acceptable

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977
Reference Type:
publication
Title:
Acute toxicologic evaluation of methylmercaptobenzimidazole
Author:
Bomhard E, Loeser E
Year:
1996
Bibliographic source:
J Am Coll Toxicol 15, S65

Materials and methods

Principles of method if other than guideline:
A dose of 50 mg of the test substance was administered into one eye of one male and one female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of the ocular reaction was recorded until day 7 according to Draize et al. (J. Pharmacol. Exp. Ther. 82, 377-390 (1944)).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Versuchsprodukt KA 9059 = Vulkanox MB-2/MG; no further data

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
1 day
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 animals

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1 h, 24 h, 2 d, 3 d, 6 d, 7 d
Score:
0
Max. score:
13
Reversibility:
other: not applicable - score = 0 at any time point
Other effects:
at the inspection 1 h after the application of the test substance for 24 hours a slight redness of the treated eye (score = 1) was found. This finding was reversible within 24 h (score = 0).

Any other information on results incl. tables

The test substance proved to be not irritating to the eye

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

A dose of 50 mg of the test substance was administered into one eye of one male and one female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of the ocular reaction was recorded until day 7 according to Draize et al. (J. Pharmacol. Exp. Ther. 82, 377-390 (1944)).

The test substance was not irritating to the eye (score = 0 at any time point).