Registration Dossier
Registration Dossier
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EC number: 247-304-1 | CAS number: 25869-00-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Enhancement of the Excretion of Radiocaesium in Rats by Ferric cyanoferrrate
- Author:
- Nigrovic, V
- Year:
- 1 963
- Bibliographic source:
- Int. J. Rad. Biol.7,3,307-309
Materials and methods
- Principles of method if other than guideline:
- Carrier-free 137CsCl and Ferric cyanoferrate (II) (Fe4[Fe(CN)6]3) were administered separately by a gastric tube to rats, who fasted for 20 hours, and the retention of 137Cs assayed by whole- body counting.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ferric cyanoferrate
- IUPAC Name:
- Ferric cyanoferrate
- Details on test material:
- - Name of test material: Ferric cyanoferrate (II)
- Molecular formula: (Fe4[Fe(CN)6]3)
Constituent 1
Results and discussion
Any other information on results incl. tables
The results show a pronounced suppression of the enteral 137Cs- absorption even if ferric cyanoferrate (II) was given as late as 60 min after 137Cs -administration.
Since no toxic side- effects were observed even for the highest dosage of Ferric cyanoferrate (II) used, this findings suggest the therapeutic applicability of this agent in cases of accidental incorporation of radiocaesium.
Table 1. 137Cs- retention by rats (96 hours after its oral application) as influenced by oral administration of ferric cyanoferrate (II). Five animals per groups.
Ferric cyanoferrate (II) |
Body weight (grams) |
Percentage of 137Cs- dose (95 per cent fiducial limits) |
Percentage of control |
|
Dosage (mg/ animal) |
Time of administration (minutes after 137Cs) |
|||
0 |
- |
219 |
58.1 (63.3-53.4) |
100 |
1 |
2 |
215 |
9.42 (13.2-6.72) |
16 |
10 |
‘’ |
203 |
1.17 (1.64-0.84) |
2 |
50 |
‘’ |
186 |
0.57 (0.80-0.41) |
1 |
100 |
‘’ |
188 |
0.52 (0.73-0.37) |
0.9 |
0 |
- |
185 |
52.5 (51.1-51.0) |
100 |
100 |
30 |
184 |
29.2 (36.8-23.0) |
56 |
100 |
60 |
238 |
31.8 (40.2-25.2) |
61 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
