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Diss Factsheets
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EC number: 308-760-8 | CAS number: 98246-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 24 August 1998 - 4 September 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to internationally accepted guidelines and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 849705-80-2
- Cas Number:
- 849705-80-2
- IUPAC Name:
- 849705-80-2
- Reference substance name:
- -
- EC Number:
- 434-710-0
- EC Name:
- -
- IUPAC Name:
- 434-710-0
- Details on test material:
- Identity: P-2290
Chemical name: 2-Oxetanone, 3-(C14-16 and C16-unsatd. branched and linear alkyl) 4-(C15-17 and C17-unsatd. branched and linear alkylidene) derivs
Appearance: Brown waxy liquid
Storage conditions: 4°C in the dark
Batch number: No data
Composition: Alkyl ketene dimer > 85%, Toluene <20ppm
Sample receive: 8 May 1998
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England.
- Age at study initiation: 13 weeks
- Weight at study initiation: 2.4-2.8
- Housing: They were housed individually in stainless steel cages with perforated floors in Building R14 Room 5.
- Diet (e.g. ad libitum): ad libitum, a standard laboratory rabbit diet (Special Diet Services STANRAB (P) SQC pellet).
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 49-74
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 24 August 1998 - 4 September 1998
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Examination of the treated skin was made on Day 1 (ie approximately 50 minutes after removal of the dressings) and on Days 2, 3 and 4 (equivalent to 24, 48 and 72 hours after exposure). Additional observations were made for two animals on Days 5 through 8 and for one animal on Days 9 through 12.
- Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: 25 mm x 25 mm
- Type of wrap if used: gauze pad covered by "Elastoplast" adhesive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The treatment site was washed with warm water (34ºC) to remove any residualtest substance. The treated area was blotted dry with absorbent paper.
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Erythema and eschar formation:
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well-defined erythema
3 Moderate to severe erythema
4 Severe erythema (beet redness) or eschar formation (injuries in depth) preventing erythema reading
Oedema formation:
0 No oedema
1 Very slight oedema (barely perceptible)
2 Slight oedema (edges of area well-defined by definite raising)
3 Moderate oedema (edges raised approximately 1 millimetre)
4 Severe oedema (raised more than 1 millirnetre and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animal
- Time point:
- other: 24-48-72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24-48-72 hours
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritant / corrosive response data:
- Well-defined erythema with very slight oedema was seen in one animal. Very slight erythema alone was seen in one further animal. Desquamation of the stratum comeum (characterised by dryness and sloughing of skin) developed in both rabbits. These reactions had resolved completely by day 11 after exposure. No dermal irritation was observed in the remaining animal throughout the duration of the study.
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
Any other information on results incl. tables
no. |
Effect |
Min. |
Days after application |
Mean score erythema 24/48/72 h |
Mean score oedema 24/48/72 h |
||||
50 |
1 |
2 |
3 |
7 |
11 |
||||
1211 |
Erythema/ eschar Oedema |
1 0 |
2 1 |
2 1 |
2 0 |
2a 0 |
0 0 |
2 |
0.66 |
1212 |
Erythema/ eschar Oedema |
0 0 |
0 0 |
0 0 |
0 0 |
0 |
0 |
||
1213 |
Erythema/ eschar Oedema |
0 0 |
1 0 |
1 0 |
1 0 |
0a 0 |
1 |
0 |
|
Mean |
0.17 |
0.67 |
0.67 |
0.5 |
0.33 |
0 |
1 |
0.22 |
a Desquamation of the stratum corneum (characterized by dryness and sloughing of skin)
Applicant's summary and conclusion
- Conclusions:
- Based on the scores for this study the test substance is not classified for skin irritation according to OECD GHS criteria.
- Executive summary:
A study was performed to assess the skin irritation potential of P-2290 to the rabbit. The method followed was that described in: EEC Methods for the determination of toxicity, Annex to Directive 92/69/EEC (Official Journal No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (Skin Irritation).
OECD Guideline for Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion". Adopted 17 July 1992.
Three rabbits were each administered a single dermal dose of 0.5 ml of the test substance and observed for up to 11 days after exposure. A single semi-occlusive application of P-2290 to intact rabbit skin for four hours elicited very slight to well-defined dermal erythema and slight oedema. Based on the scores for this study the test substance is not classified for skin irritation according to OECD GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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