Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402 (1987)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Dastib 845
- IUPAC Name:
- Dastib 845
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: 7 days
kept individually
temperature: 22±2°C
humidity: 50-70%
comercial diet
water: ad libitum
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- olive oil
- Details on dermal exposure:
- 24 h before application hair was cut down from 10% of total surface area covered by non irritating tape for 24 h and then removed with olive oil observation period: 14 days.
- Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
- Statistics:
- Student T-Test
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Nach Ablauf des Ausstellungszeitraums wurden keine systemischen Toxizitatserscheinungen festgestellt. Auch einen oder zwei Tage spater wurden keine Toxizitatserscheinungen beobachtet. Following the end of the exh
- Gross pathology:
- Effects on organs: Die Nekrosebefunde und histopathologischen Veranderungen waren negativ.
The necrosis bias results and histopathological changes
were negative. - Other findings:
- Signs of toxicity (local):
Nach Ablauf des Ausstellungszeitraums von 24 Stunden wurden
keine ortlichen Toxizitatserscheinungen festgestellt. Auch
einen oder zwei Tage spater wurden keine
Toxizitatserscheinungen beobachtet.
Following the end of the exhibition period of 24 hours
no local toxicity adverse effect was identified. Also
one or two days later were not
adverse effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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