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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-237-5 | CAS number: 10099-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles. Non-standard treatment regimen.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
- Principles of method if other than guideline:
- Maternal rats were exposed to lanthanum from gestation day 0 through postnatal day 20. From postnatal day 20, pups were exposed to Lanthanum until postnatal day 150. Physical and neurobehavioural development of the pups was recorded, the DNA and protein/DNA concentrations were determined at postnatal day 30 and the Morris water mate test was conducted at postnatal day 150.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Lanthanum Chloride
- Molecular formula (if other than submission substance): LaCl3
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Center of Beijing Medical University
- age: 7-9 weeks
- Housing: 5 in a polycarbonate cage
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- other: oral: probably gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Details on mating procedure:
- - Female rats were mated with males of the same age and strain
- Proof of pregnancy: vaginal plug [day 0] of pregnancy
- No information about: length of cohabitation, success of copulation
- After successful mating each pregnant female was caged individually - Duration of treatment / exposure:
- Dams: from gestation day 0 through postnatal day 20
Pups: from postnatal day 20 until they were killed (postnatal day 150) - Frequency of treatment:
- probably daily during treatment period
- Duration of test:
- 150 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.1, 2 and 40 mg/kg/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- 15 maternal rats/dose
a total of 30 pups (equal numbers of males and females when possible) per dose - Control animals:
- yes, concurrent no treatment
Results and discussion
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 40 mg/kg bw/day (nominal)
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
- No differences in litter size between groups.
- No differences in pinna detachment and eye opening between groups.
- Body weights showed no significant differences among all groups on the 0 day. Compared to other groups, although no significant difference was observed, the body weight of the 2 mg/kg group was elevated on PND0 and PND30, with a significant difference on PND90. However, the weight gain of the 40 mg/kg group was decreased at all ages, with a significant difference at 5 months. This was not regarded a biologicallly significant effect.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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