Registration Dossier
Registration Dossier
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EC number: 233-237-5 | CAS number: 10099-58-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro
There are no in vitro mutagenicity data for Lanthanum chloride. Thus, read-across from the structural analogues Lanthanum nitrate (CAS 10277-43-7) and Lanthanum carbonate (CAS 587-26-8) was performed.
Lanthanum nitrate tested negative in an Ames assay usingSalmonella thyphimuriumstrains TA100, TA1535, TA97 and TA98 in the presence and absence of a metabolic activation system (Zeiger et al., 1992). In addition, in a reliable study performed according to OECD 476, treatment with Lanthanum carbonate did not induce mutations in Chinese Hamster Ovary (CHO) cells.
In vivo
Genetic toxicity in vivo was evaluated in a published micronucleus test performed according to OECD 474 (Damment et al., 2005). Groups of six male Sprague-Dawley rats received intraveneous injections of an aqueous solution containing 0.025, 0.05 and 0.1 mg/kg Lanthanum chloride and were sacrificed 24 or 48 hours later. In addition, blood was taken from animals of a accompanying satellite group 2, 15 and 60 min after administration in order to determine the plasma lanthanum concentration. As result, no overt toxicity was seen and no increase in micronucleus frequency was observed in any dose group.
The same publication also reported an unscheduled DNA synthesis (UDS) study which was performed according to OECD 486 with the exemption that the animals were not dosed once but repeatedly for 28 days. Briefly, 3 male Han Wistar rats received daily injections of 0.025, 0.05 and 0.1 mg/kg/d Lanthanum chloride for 28 days. 12-14 hours after the last application, the livers were perfused with collagenase and hepatocytes were isolated. After following exposure to [3H]thymidine, the measurement of UDS was carried out by autoradiographic analysis from 100 morphologically normal cells per animal. No increase in the unscheduled DNA synthesis was found in all dose groups.
Short description of key information:
- in vitro: negative (Ames and HPRT assay)
- in vivo: negative (micronucleus assay)
Endpoint Conclusion:
Justification for classification or non-classification
There are conclusive data available, but they are not sufficient for classification.
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