Registration Dossier
Registration Dossier
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EC number: 429-270-1 | CAS number: 136210-30-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The assessment of the toxicokinetics of the structural analogue Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-,1,1',4,4'-tetraethyl ester is based on physico-chemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.
Data source
Reference
- Reference Type:
- other: Toxicokinetic assessment
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
- Principles of method if other than guideline:
- assessment on toxicokinetics
Test material
- Reference substance name:
- 136210-32-7
- EC Number:
- 603-947-3
- Cas Number:
- 136210-32-7
- IUPAC Name:
- 136210-32-7
- Reference substance name:
- Bis(4-(1,2-bis(ethoxycarbonyl)ethylamino)-3-methylcyclohexyl)methane
- EC Number:
- 412-060-9
- EC Name:
- Bis(4-(1,2-bis(ethoxycarbonyl)ethylamino)-3-methylcyclohexyl)methane
- Cas Number:
- 136210-32-7
- Molecular formula:
- C31H54N2O8
- IUPAC Name:
- bis(4-(1,2-bis(ethoxycarbonyl)ethylamino)-3-methylcyclohexyl)methane
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
The toxicokinetic was assessed considering physico-chemical properties and toxicological data from aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester, which is a structural analogue to aspartic acid, N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, 1,1',4,4'-tetraethyl ester. Both substances are diethyl esters of aspartic acid linked to a dicyclohexylmethyldiamine moiety. The difference between these two substances is merely the presence of two methyl groups connected to the cyclohexane rings. This structural analogy was confirmed by the Member State responsible for the notification of both substances under the NONS regulation. The Member State decided that test results obtained for one substance can be transferred to the other substance and that testing of both substances is usually not required. This decision is in accordance with the grouping of substances and read-across approach in Annex XI, 1.5 of the REACH Regulation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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