Registration Dossier
Registration Dossier
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EC number: 429-270-1 | CAS number: 136210-30-5
Endpoint summary
Administrative data
Description of key information
Additional information
The effect of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards mortality of earthworm Eisenia fetida was tested according to the OECD Guideline No. 207. The test item did not evoke mortality towards earthworm at concentrations up to and including 1000 mg a.s./kg (ECT Oekotoxikologie GmbH, 2009a).
The effect of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards seedling emergence and seedling growth of terrestrial plants was tested according to the OECD Guideline No. 208. The test item had no adverse effects on seedling emergence and growth of higher plants at concentrations up to and including 100 mg a.s./kg soil dry mass
(ECT Oekotoxikologie GmbH, 2009b).
Read across justification:
Studies were performed with aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester which is a structural analogue to aspartic acid, N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, 1,1',4,4'-tetraethyl ester. Both substances are diethyl esters of aspartic acid linked to a dicyclohexylmethyldiamine moiety. The difference between these two substances is merely the presence of two methyl groups connected to the cyclohexane rings. This structural analogy was confirmed by the Member State responsible for the notification of both substances under the NONS regulation. The Member State decided that test results obtained for one substance can be transferred to the other substance and that testing of both substances is usually not required. This decision is in accordance with the grouping of substances and read-across approach in Annex XI, 1.5 of the REACH Regulation.
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