Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-410-8 | CAS number: 3087-36-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable. Therefore, the long-term toxicity of the main decomposition product ethanol is used as a key value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.6 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 79 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than ethanol and hydrated titanium dioxide (half-life < 5 minutes, Brekelmans M.J.C. 2013). The organic decomposition product ethanol is readily biodegradable having also a low log Kow value (-0.3). The CSA indicates that toxicity of this substance is similar to the main degradation product ethanol. Key studies (short-term toxicity to daphnia and algae, Klimisch score 1) conducted for the analogue category member (titanium tetraisopropanolate, CAS 546-68-9) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.
Therefore, the long-term toxicity study on invertebrates is unjustified, and the key value for CSA is obtained from the most reliable existing data on ethanol. According to Cowgill & Milazzo (1991), the 10-d NOEC of ethanol to Ceriodaphnia dubia and Daphnia magna (reproduction) in freshwater is 9.6 mg/l based on criteria of total progeny, number of broods and mean brood size. This study was well reported and considered as reliable to be used as a weight of evidence to evaluate the long-term toxicity of the target substance in freshwater.
According to Rayburn & Fisher (1997), 12-d NOEC (developmental delay of embryos) of ethanol to Palaemonetes pugio in saltwater is 79 mg/l based on nominal concentrations. This study was considered acceptable with sufficient basic documentation to demonstrate that the results meet basic scientific principles.
This study was considered reliable to be used as a weight of evidence to evaluate the long-term toxicity of the target substance in saltwater.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
