Registration Dossier
Registration Dossier
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EC number: 221-410-8 | CAS number: 3087-36-3
Endpoint summary
Administrative data
Description of key information
Additional information
Titanium (4 +) ethanolate is hydrolytically unstable. The progress of the hydrolysis was followed by monitoring ethanol (EtOH), the main degradation product of the substance (Brekelmans 2013). The other non-hazardous degradation product (hydrated titanium oxide) is insoluble lacking bioavailability in aquatic environment, and therefore not further considered in CSA.
Because of the rapid hydrolysis of this substance, the intrinsic properties of aquatic toxicity are related to the main degradation product (EtOH). This was also demonstrated in the aquatic toxicity key studies (daphnia and algae) conducted for the analogue category member (Titanium tetraisopropanolate CAS 546-68-9). In the studies of this analogue category member, due to the rapid hydrolysis in aqueous test media, the degradation products (IPA and hydrated titanium dioxides) toxicity to the freshwater invertebrates and algae were investigated based on the measured IPA concentrations and the equivalent test item concentrations.The category justification is presented in the annex of the CSR.
Based on the high reactivity of this substance in water, the short-term and long-term aquatic toxicity testing was considered scientifically unjustified and the supporting read-across data from the main degradation product (EtOH) was used as a key value in CSA.
Short-term toxicity to fish:
•96-h LC50 (mortality) to Pimephales promelas; 14 200 mg/L based on measured concentrations (read-across from EtOH; Brooke et al. 1984)
Short term and long-term toxicity to invertebrates:
•48-hour LC50 (immobilisation) to Ceriodaphnia dubia; 5 012 mg /l based on nominal concentrations. (read-across from EtOH; Takahashi et al. 1987)
•10-d NOEC (reproduction) to Ceriodaphnia dubia and Daphnia magna; 9.6 mg/l based on nominal concentrations. (read-across from EtOH; Cowgill & Milazzo 1991)
Toxicity to algae:
•The 72h-EC10 (growth rate) to Chlorella vulgaris; 11.5 mg /l based on measured nominal (OECD 201; read-across from EtOH; El Jay 1996)
•The 72h-EC50 (growth rate) to Chlorella vulgaris; 275 mg /l based on measured nominal (OECD 201; read-across from EtOH ; El Jay 1996)
Toxicity to micro-organisms:
•LC50 (mortality) to Paramaecium caudatum; 5 800 mg/l based on nominal concentrations (read-across from EtOH; Rajini et al. 1989)
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