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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Six groups of 5 male and 5 female Wistar rats were nose/head-only exposed to analytical concentrations of 0, 375.6, 906.5, 1968.9, 3292.8 or 7619.5 mg 3-chloro-p-toluidine/m³ air for 4 hours. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-p-toluidine
EC Number:
202-446-3
EC Name:
3-chloro-p-toluidine
Cas Number:
95-74-9
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-4-methylaniline
Test material form:
aerosol dispenser: not specified
Details on test material:
3-chloro-p-toluidine (technically pure); purity: 99.5 %; vehicle: mixture of polyethylene glycol 400 and ethanol (1:1)

0,20 % p-Toluidine
0,01 % 4-Chlor0-3-toluidine
0,02 % 2-Chloro-4-nitrobenzene
99,5 % 2-Chloro-4-toluidine
0,03 % 6-Chlor0-3-toluidine
0,06 % 2,5-Dichloro-4-toluidine
0,07 % 2,6-Dichloro-4-toluidine + 3,4-Dichloranilin
0,06 % unknown compounds(5 compounds)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
other: polyethylenglycol - ethanol 1:1
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
0, 375.6, 906.5, 1968.9, 3292.8 or 7619.5 mg 3-chloro-p-toluidine/m³ air.
No. of animals per sex per dose:
5 male and 5 female rats/dose
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 7.62 mg/L air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables

At 7620 mg 3-chloro-p-toluidine/m³ air (maximal examined concentration) one of five female rats died. Clinical signs were a low irritation potential of mucuous membranes, methamoglobinemia and unspecific central nervous symptoms.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Six groups of 5 male and 5 female Wistar rats were nose/head-only exposed to analytical concentrations of 0, 375.6, 906.5, 1968.9, 3292.8 or 7619.5 mg 3-chloro-p-toluidine/m³ air for 4 hours. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.

At 7620 mg 3-chloro-p-toluidine/m³ air (maximal examined concentration) one of five female rats died. Clinical signs were a low irritation potential of mucuous membranes, methamoglobinemia and unspecific central nervous symptoms.

LC50 > 7.69 mg/L.