3-chloro-p-toluidine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given.

Principles of method if other than guideline:

Bidest water and superplus of compound were stired at 20 °C for 3 to 4 days in a temperated waterbath; subsequently filtered centrifuged. HPLC or GC analysis was used to determine compound concentrations.

GLP compliance:

not specified

Type of method:

flask method

Water solubility:

2 650 mg/L

Temp.:

20 °C

Remarks on result:

other: pH not reported

pH not given.

Executive summary:

Water solubility of 3-chloro-p-toluidine was determined to be 2650 mg/L at 20 °C, pH was not given in this assessment. Since dissociated substance usually shows a (slightly) increased water solubility, causing an elevated exposure to aquatic organisms, water solubility should be determined with temperature and pH. However, derived from a pKa value of 3.9 it may be assumed that most of the compound will not be dissociated at pH ranges in the environment. Thus, water solubility of the compund is not significantly underestimated.

Description of key information

Water solubility of 3-chloro-p-toluidine was determined to be 2650 mg/L at 20 °C, pH was not given in this assessment. Since dissociated substance usually shows a (slightly) increased water solubility, causing an elevated exposure to aquatic organisms, water solubility should be determined with temperature and pH. However, derived from a pKa value of 3.9 it may be assumed that most of the compound will not be dissociated at pH ranges in the environment. Thus, water solubility of the compund is not significantly underestimated.

Key value for chemical safety assessment

Water solubility:

2 650 mg/L

at the temperature of:

20 °C