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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The case report is from exposure to a mixture of chemicals, only 7% of which is vinylpyridine. A strong association between cause and effect cannot be made.
Data source
Reference
- Reference Type:
- publication
- Title:
- Vinylpyridine: an unusual casue of a chemical burn
- Author:
- Stone CA and K Dunn
- Year:
- 1 996
- Bibliographic source:
- Burns 22:150-151.
Materials and methods
- Study type:
- other: case report
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Report of one case of a burn to a chemical exposure. The chemical is part of a mixture from a container 12 years old; it is not specifically identified as 2-VP
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
Constituent 1
Method
- Type of population:
- occupational
Results and discussion
- Clinical signs:
- His initial reaction was contact dermatitis. It suddenly worsened 5 days later, when he sought medical attention for left-sided deep calf pain.
- Results of examinations:
- Five days after a spill to the leg of a 12-year old mixture of chemicals, 7% of which was an unspecified isomer of vinylpyridine, the leg area displayed livid erythema and marked swelling of the lower legs. There was also increased local temperature and superficial paraesthesia. The affected area was well demarcated over the left foot. The appearance was consistent with a superficial partial thickness burn.
- Outcome of incidence:
- After 10 days of medical treatment, the erythema and dermal aedema was significantly improved, leaving areas of patchy skin discolouration.
Any other information on results incl. tables
The main constituent of the original chemical was subsequently identified by mass spectroscopy as 7% m/m vinylpyridine, although the isomeric and polymeric status were unknown.
Applicant's summary and conclusion
- Conclusions:
- This is a case report of a burn to the skin of a worker from a mixture of chemicals 12 years old. The identify of the main constituent was a vinylpyridine, although the isomeric identity was not established. Contact dermatitis progress into a deep tissue burn after 5 days. After another 10 days of medical treatment, the burn was significantly healed.
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