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EC number: 275-965-6 | CAS number: 71735-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of the toxicokinetic behavior
The test substance (molecular weight of 314 g/mol) is a clear, slightly yellow liquid (BASF, 2012) with a vapor pressure of 0.065 Pa at 20°C (BASF, 2013). The substance is characterized with a water solubility of 16.7 mg/l (BASF, 2013) and good solubility in organic solvents (> 100 g/l in ethanol, aceton and toluol, Ciba-Geigy, 1989). The log Pow was determined to be 4.0 at a temperature of 23°C (BASF, 2013). No studies are available investigating the toxicokinetic properties of the test substance. The toxicokinetic behavior is therefore assessed based on physic-chemical properties and on available toxicity studies.
Absorption
Absorption through the gastrointestinal tract is favored for a molecular weight below 500 g/mol (ECHA GD 7c, 2008). In addition, moderate log Pow values are favorable for absorption by passive diffusion. Therefore, based on the physico-chemical parameters, absorption of the test article after oral exposure is expected. This is in line with the data obtained by a subacute oral repeated dose toxicity study (Harlan, 2012). Here, hepatocellular hypertrophy was observed histologically in males of the high dose group (500 mg/kg bw/day), which was considered to be an adaptive change due to increased metabolic load. Increased incidence and severity of tubular basophilia in the kidneys were observed in females at 500 mg/kg bw/day. These findings demonstrate that absorption of the test article has occurred.
Dermal uptake is favored for chemicals with a molecular weight < 100 g/mol, while for chemicals with a molecular weight > 500 g/mol, dermal uptake is not favored (ECHA GD 7c,2008). In addition, Log P values between 1 and 4 favor dermal absorption. With a molecular weight of 314 g/mol and a log P of 4.0, the test article is possibly absorbed through skin. The available toxicity data does not give any indications for dermal penetration. In a guinea pig maximization test the substance was negative (RCC, 2001). However, this result does not rule out dermal absorption and based on the physico-chemical data, dermal penetration is expected.
No information from acute or repeated dose toxicity studies is available, which could provide information about the systemic distribution of the test substance after inhalation. Upon exposure to aerosol or vapors absorption through the respiratory tract is expected.
Metabolism
Considering the hepatocellular hypertrophy observed in the subacute toxicity study, the substance or one of the major components is likely to be subject to hepatic metabolism.
Excretion
Smaller molecules (< 300 g/mol) tend to be excreted in the urine, especially when they are soluble in water. Larger molecules are expected to be eliminated via biliary excretion. The test substance is predicted to be metabolized and broken down to smaller molecules in the liver. Upon phase II metabolism in the liver the water solubility of these smaller breakdown products is increased and excretion is expected to occur predominantly via urine. Some excretion might also occur through feces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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