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EC number: 203-807-8 | CAS number: 110-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Cyclohexene
- EC Number:
- 203-807-8
- EC Name:
- Cyclohexene
- Cas Number:
- 110-83-8
- Molecular formula:
- C6H10
- IUPAC Name:
- cyclohexene
- Details on test material:
- - Analytical purity:98.6wt%
- Impurities (identity and concentrations):0.01wt% BHT(2,6-Di-tert-butyl-4-methylphenol) is included as antioxidant
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Charles River Japan
- Age at study initiation:6 weeks
- Weight at study initiation:male 161-181g, female 122-140g
- Fasting period before study:16hr
- Housing:5/cage
- Diet (e.g. ad libitum):ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):23.2-24.4
- Humidity (%):50-64
- Air changes (per hr):20/hr
- Photoperiod (hrs dark / hrs light): 12hr/12hr
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:100, 200 and 400mg/mL
- Amount of vehicle (if gavage):0.5mL/100g body weight
MAXIMUM DOSE VOLUME APPLIED:2000mg/kg - Doses:
- 0 (vehicle), 500, 1000, 2000 mg/kg
- No. of animals per sex per dose:
- Males, 5; females, 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:1, 3, 7 and 14day
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Mortality:
- Each 3 of 5 animals of male and female rats at 2,000 mg/kg b.w. died within 3 days after dosing.
Dose(mg/kg b.w.) 0 500 1000 2000
No.of animals 5 5 5 5
No.of death Male 0 0 0 3
No.of death Female 0 0 0 3
Mortanity Male 0 0 0 60%
Mortanity Female 0 0 0 60%
- Clinical signs:
- other: Each 3 of 5 animals of male and female rats at 2,000 mg/kg b.w. showed abnormal gait, adoption of a prone position, salivation, piloerection and tremor, and then died within 3 days after dosing. Hypoactivity was observed in all male and female rats given
- Gross pathology:
- Necropsy of the dead animals revealed pulmonary congestion. Abnormal gait, adoption of a prone position, salivation, piloerection and tremors were also observed in some animals before death.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 values are between 1000 and 2000mg/kg b.w. for both sexes. Therefore, cyclohexene is classified as Category 4 of Acute toxicity (oral) according to CLP(GHS).
- Executive summary:
The LD50 values are between 1000 and 2000mg/kg b.w. for both sexes. Therefore, cyclohexene is classified as Category 4 of Acute toxicity (oral) according to CLP(GHS) .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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