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Diss Factsheets
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EC number: 474-870-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
see justification attached in section 13 - Reason / purpose for cross-reference:
- read-across source
- Test performance:
- No oxygen consumption by nitrification has been observed in the flask with test item at the end of the test.
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 5
- Sampling time:
- 28 d
- Details on results:
- All validity criteria of the test method were met:
The reference compound has reached the level for ready biodegradabiiity by 14 days.
No toxicity of the test item has been observed in the toxicity control.
The difference of extremes of replicate values of the removal of test chemical at the end of the test is less than 20 %.
The oxygen uptake of die inoculum blank is < 60 mg/1.
The pH between 6.0 and 8.5 in the test vessels at the end of the test (if degradation is less than 60 %).
Oxygen uptake by nitrification has been determined. The oxygen consumed by nitrification was 0 mg/1. - Results with reference substance:
- The reference compound showed 90 % degradation after 14 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Within 28 days, a degradation of 5 % was determined.
The test substance, by analogy of read across, has to be classified as "Not Readily Biodegradable". - Executive summary:
A study was performed to assess the ready biodegradability of the strucural analogue. The study was conducted in accordance with the Council Directive 92/69/EEC Method C.4-D "Manometric Respirometry Test". This test method is in all essential parts identical with OECD Guideline 301 F.Study performed in accordance with the Principles Good Laboratory Practice (GLP).
A solution of the test substance in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period the ready biodegradability is determined.
The structural analogue showed no relevant biodegradation throughout the testing period; therefore, the test substance, by analogy of read across,has to be classified as "Not Readily Biodegradable"
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 October 2003 to 13 November 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Type: mixed population of aquatic microorganisms (activated sludge)
Origin: aeration tank of a waste water plant treating predominantly domestic sewage (Wupper area water authority)
Date of collection: 2003-10-15
Pre-treatment: none
Concentration of inoculums: 30mg/lss - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Pre-treatment of the test item: 25 mg test item were weighed out on aluminium foil. This substance inclusive the aluminium foil was added to the test vessels to give a test concentration of 100 mg/1 test item.
Exposure conditions
Test volume: 250 ml
Test apparatus: Voith Sapromat
Mixing: 1 magnetic stirrer per test vessel
Incubation time: 28 days
Incubation temperature: 22 + 2°C - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- No data
- Test performance:
- No oxygen consumption by nitrification has been observed in the flask with test item at the end of the test.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 5
- Sampling time:
- 28 d
- Details on results:
- All validity criteria of the test method were met:
The reference compound has reached the level for ready biodegradabiiity by 14 days.
No toxicity of the test item has been observed in the toxicity control.
The difference of extremes of replicate values of the removal of test chemical at the end of the test is less than 20 %.
The oxygen uptake of die inoculum blank is < 60 mg/1.
The pH between 6.0 and 8.5 in the test vessels at the end of the test (if degradation is less than 60 %).
Oxygen uptake by nitrification has been determined. The oxygen consumed by nitrification was 0 mg/1. - Results with reference substance:
- The reference compound showed 90 % degradation after 14 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Within 28 days, a degradation of 5 % was determined.
The test substance has to be classified as "Not Readily Biodegradable". - Executive summary:
A study was performed to assess the ready biodegradability of the test substance. The study was conducted in accordance with the Council Directive 92/69/EEC Method C.4-D "Manometric Respirometry Test". This test method is in all essential parts identical with OECD Guideline 301 F.Study performed in accordance with the Principles Good Laboratory Practice (GLP).
A solution of the test substance in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period the ready biodegradability is determined.
The test substance showed no relevant biodegradation throughout the testing period; therefore, the test substance has to be classified as "Not Readily Biodegradable"
Referenceopen allclose all
0% degradation after 4 days.
1% degradation after 6 days.
1% degradation after 8 days.
1% degradation after 12 days.
3% degradation after 14 days.
4% degradation after 18days.
3% degradation after 20 days.
2% degradation after 22 days.
3% degradation after 26 days.
5% degradation after 28 days
0% degradation after 4 days.
1% degradation after 6 days.
1% degradation after 8 days.
1% degradation after 12 days.
3% degradation after 14 days.
4% degradation after 18days.
3% degradation after 20 days.
2% degradation after 22 days.
3% degradation after 26 days.
5% degradation after 28 days
Description of key information
The structural analogue showed no relevant biodegradation throughout the testing period; therefore, the test substance, by analogy of read across, has to be classified as "Not Readily Biodegradable"
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
A study was performed to assess the ready biodegradability of the strucural analogue.The study was conducted in accordance with the Council Directive 92/69/EEC Method C.4-D "Manometric Respirometry Test". This test method is in all essential parts identical with OECD Guideline 301 F.Study performed in accordance with the Principles Good Laboratory Practice (GLP).
A solution of the test substance in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period the ready biodegradability is determined.
The structural analogue showed no relevant biodegradation throughout the testing period; therefore, the test substance, by analogy of read across,has to be classified as "Not Readily Biodegradable"
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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