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Diss Factsheets
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EC number: 256-367-4 | CAS number: 49553-76-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
- Principles of method if other than guideline:
- The HET-CAM was used to measure irritation potential of chemicals following the protocol published in the 1990s by the cosmetic industry (Brantom et al., 1997, Toxicology In Vitro, 11, 141-179; Steiling et al., 1999, Toxicology In Vitro, 13, 375-384; Sterzel et al., 1990, Toxicology In Vitro, 4, 698-701) and was evaluated in a number of studies including the European COLIPA validation study (Brantom et al., 1997, Toxicology In Vitro, 11, 141-179). The results were obtained either using the Reaction Time Method (RT) (Steiling et al., 1999, Toxicology In vitro, 13, 375-384).
- GLP compliance:
- yes
Test material
- Reference substance name:
- 67965-56-4
- EC Number:
- 614-187-7
- Cas Number:
- 67965-56-4
- IUPAC Name:
- 67965-56-4
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 9-Octadecanoic acid (Z)-diester with oxybis[propanediol]
- Physical state: liquid
- Analytical purity: 100 %
Constituent 1
Test animals / tissue source
- Species:
- other: in vitro
- Strain:
- other: chicken eggs
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: internal standard (5% aqueous solution of sodium magnesium lauryl-myristyl-6-ethoxysulfate) with well-known irritating potential was used as benchmark for categorization of irritation potential
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 300 µL or sufficient amount to cover at least 25% of the CAM
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 300 seconds
- Observation period (in vivo):
- 300 seconds
- Number of animals or in vitro replicates:
- 2 eggs in pretest and 6 eggs in main test
- Details on study design:
- SCORING SYSTEM:
Effects: occurrence of specific effects on the CAM and/or its blood vessels, H - Hemorrhage, L - Lysis, C - intravasal and/or extravasal coaggulation
RT scores - individual time of occurrence of effects were recorded during a maximum observation period of 300 seconds, a test item specific irritation score was determined by equal valuation of individual effects without using ranking factors. The benchmark chemical was tested in parallel and both irritation scores (mean over all eggs) were used to calculate the Q-value (quotient of both scores). This Q-value is the relevant parameter for prediction of irritancy classes (see table 1 under "Any other information on material and methods including tables").
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Q-score
- Basis:
- mean
- Remarks:
- egg#1 - egg#6
- Time point:
- other: up to 300 seconds
- Score:
- < 1.2
- Irritant / corrosive response data:
- no details given
- Other effects:
- no other effects stated
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DSD: not classified
CLP: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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