Registration Dossier
Registration Dossier
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EC number: 256-367-4 | CAS number: 49553-76-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) = 1.85 mg/L (measured TWA) for Daphnia magna (OECD 211); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity to aquatic invertebrates of Oleic acid, monoester with oxybis(propandiol) (CAS 49553-76-6) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to a structurally related analogue substance 2,3-dihydroxypropyl oleate (CAS 111-03-5) was conducted. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. Short-term data for aquatic invertebrates show a consistent pattern of results for Oleic acid, monoester with oxybis(propandiol) (EC50 (48h) = 37.5 mg/L) and the read-across substance 2,3-dihydroxypropyl oleate (EC50 (48h) = 49 mg/L). Therefore, similar chronic toxicity is expected for daphnia for both substances and the read-across from 2,3-dihydroxypropyl oleate for long-term daphnia is justified.
The study with 2,3-dihydroxypropyl oleate (CAS 111-03-5) was performed according to OECD 211 under GLP conditions (MOE, 2001). Daphnia magna was exposed to six measured concentrations (measured TWA) between < 0.91 and 36.3 mg/L in a semi-static test for 21 days resulting in a NOEC = 1.85 mg/L (meas. TWA).
Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), characterized by a similar ecotoxicological profile, it can be concluded that Oleic acid, monoester with oxybis(propandiol) will show similar chronic toxicity to aquatic invertebrates.
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