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Registration Dossier
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Diss Factsheets
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EC number: 203-552-2 | CAS number: 108-12-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Valeryl chloride
- EC Number:
- 211-330-1
- EC Name:
- Valeryl chloride
- Cas Number:
- 638-29-9
- IUPAC Name:
- pentanoyl chloride
- Details on test material:
- - Physical state / appearance: liquid / colourless, clear
- Substance number: 96/184
- Batch number: Vers. 130/U
- Analytical purity: 99.4%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Supplier: Dr. K. Thomae GmbH, Biberach, FRG
- Age at study initiation: young adult female
- Weight at study initiation: 4.00 kg
- Housing: stainless steel wire mesh cages with grating, floor area 3000 cm2; single housing; no bedding in the cages, sawdust in the waste trays
- Diet: ca. 130 g KLIBA-labordiaet 341 (Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland) per animal per day
- Water: 250 ml tap water per animal per day
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 -24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: the fur was removed by clipping
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied): 0.5 ml - Duration of treatment / exposure:
- 3 min and 1 h
- Observation period:
- 1 and 24 h
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: idealbinde, Pfälzische Verbandtstoff-Fabrik, Kaiserslautern) and Fixomull® strech (adhesive fleece), Beiersdorf AG
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol® E 400 (Polyethylene glycol DAB, BASF AG) and Lutrol®:water (1:1)
- Time after start of exposure: 3 min and 1 h
SCORING SYSTEM: acccording to OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 3 min of exposure
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: necrosis, index for erythema of the surrounding area
- Irritation parameter:
- erythema score
- Remarks:
- 3 min of exposure
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- other: necrosis, index for erythema of the surrounding area, study discontinued because of severe irritation
- Irritation parameter:
- erythema score
- Remarks:
- 1 h of exposure
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: necrosis, index for erythema of the surrounding area
- Irritation parameter:
- erythema score
- Remarks:
- 1 h of exposure
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- other: necrosis, index for erythema of the surrounding area, study discontinued because of severe irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 min of exposure
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: necrosis, edema extending beyond the area of exposure
- Irritation parameter:
- edema score
- Remarks:
- 3 min of exposure
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: necrosis, edema extening beyond the area of exposure, study discontinued because of severe irritation
- Irritation parameter:
- edema score
- Remarks:
- 1 h of exposure
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: necrosis, edema extending beyond the area of exposure
- Irritation parameter:
- edema score
- Remarks:
- 1 h of exposure
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- other: necrosis, edema extending beyond the area of exposure, study discontinued because of severe irritation
- Irritant / corrosive response data:
- Full thickness necrosis (assessed by histopathological examination) was observed at all exposure durations and erythema and edema were observed beyond the area of exposure. The study was discontinued because of severe skin irritation.
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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