Registration Dossier
Registration Dossier
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EC number: 203-552-2 | CAS number: 108-12-3
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: In contact with water the substance will hydrolyse rapidly.
Hydrolysis product: Isovaleric acid is readily biodegradable.
Key value for chemical safety assessment
Additional information
Parent compound: Based on a weight-of-evidence approach, isovaleryl chloride is determined to hydrolyse rapidly to isovaleric acid and HCl. This is confirmed by read across to the analogue substances stearoyl chloride (CAS 112 -76 -5), 2 -ethylhexanoyl chloride (CAS 760 -67 -8), pivaloyl chloride (CAS 3282 -30 -2), neodecanoyl chloride (CAS 40292 -82 -8) and nonanyl chloride (CAS 764 -85 -2). All these compounds hydrolyse rapidly (<< 24 h) to the corresponding acid and HCl.
The measured data are supported by HYDROWIN 2.00 data which indicate that alkyl halides usually have hydrolytic half-lives of less than 10 minutes.
Hydrolysis product: In accordance with column 2 of REACH Annex VII, the study does not need to be performed if the substance is readily biodegradable or inorganic. Isovaleryl chloride hydrolyses rapidly and forms isovaleric acid and HCl. Isovaleric acid is readily biodegradable (weight-of-evidence approach), while HCl is inorganic.
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