Registration Dossier
Registration Dossier
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EC number: 202-216-2 | CAS number: 93-08-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin irritation toxicity study of the test chemical
- Author:
- D. L. J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology,1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To determine skin irritation potential of test chemical in human using patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2'-acetonaphthone
- EC Number:
- 202-216-2
- EC Name:
- 2'-acetonaphthone
- Cas Number:
- 93-08-3
- Molecular formula:
- C12H10O
- IUPAC Name:
- 1-(naphthalen-2-yl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): 2'-acetonaphthone
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 24 hr
- Observation period:
- no data
- Number of animals:
- 24 human subjects
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- no data
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- During 24hr produced one irritation reaction in 24 human subjects
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Patch test was done in 24 human subjects. Test chemical at full strength for 24 hr produced one irritation reaction in 24 human subjects. Since the test chemical was irritant, it was considered as irritating to human skin.
- Executive summary:
In a patch test,24 human subject were involved. Test chemical at full strength for 24 hr produced one irritation reaction in 24 human subjects. Since the test chemical was irritant, it was considered as irritating to human skin.
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