2'-acetonaphthone

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data from various test chemicals

Justification for type of information:

experimental data from various test chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE report is prepared based on toxicity to microorganisms study:
1 and 2

GLP compliance:

no

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Tetrahymena pyriformis

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

60 h

Remarks on exposure duration:

48.0 h Study was conducted for 3

Reference substance (positive control):

no

Key result

Duration:

60 h

Dose descriptor:

other: IGC50

Effect conc.:

60.61 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Key result

Duration:

48 h

Dose descriptor:

other: IGC50

Effect conc.:

17 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other:

Remarks:

details not available

Validity criteria fulfilled:

not specified

Conclusions:

1: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 60.61 mg/L.
2: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 17 mg/L.
 

Executive summary:

In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –

In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.

It was determined that the IGC for WoE 1and WoE2 is 60.61 and 17 mg/L respectively

Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L

Description of key information

WoE1: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 60.61 mg/L.

WoE 2: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 17 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:

60.61 mg/L

Additional information

In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –

In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.

It was determined that the IGC for WoE 1and WoE2 is 60.61 and 17 mg/L respectively

Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L