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Diss Factsheets
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In a well conducted GLP and guideline B.7 study using Sprague-Dawley (Crl: CD VAF) rats, 60 rats (30 female and 30 male) per group were gavaged with Chiguard
380/Chiguard 380W at dose of 0mg/kg or mg/l,15 mg/kg or mg/l, 150 mg/kg or mg/l, 1000 mg/kg or mg/l for 7 days a week. Administration of the substance to the male and female rats bagan 70 days and 14 days before mating, respectively, and continued to euthanasia. In addition, a satellite group of 10 male rats were added to the high dose group (1000 mg/kg/bw) and the animals were euthanized following 28 days of exposure. The testes from these animals were preserved, proccessed, and evaluated microscopically. Another treatment group (1 mg/kg bw/day) of 30 males was also added to this study and treated as described for the main study groups with exception that males were not mated to females, and all tissues collected were preserved but microscopic examination was not conducted. At weaning, selected male pups were continued exposed on study for 67 days (90 ± 2 days of age). During this time, body weights, food consumption, and daily observations were recorded. Necropsies were conducted at termination of exposure, specified tissues were weighed and collected, and microscopic evaluation from the control and high-dose group (1000 mg/kg/day) animals were conducted. Sperm motility and concentration were evaluated in P1 and F1 males. There were no treatment related-finding. The NOAEL was 1000 mg/kg bw/day.
Short description of key information:
NOAEL(P): 1000mg/kg bw/day (EU method B.7)
Justification for classification or non-classification
Based on the available information in the dossier, the substance Chiguard 380/Chiguard 380W (CAS# 18600-59-4) need not to be classified as reproductive toxicity when considering the criteria outlined in Annex VI of 67/548/EEC and in Annex I of 1272/2008/EC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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