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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50(rat): > 5000 mg/kg bw /day (OECD 401, limit test).
Acute dermal toxicity:
LD50(rabbit): >2000mg/kg bw /day (16 CFR 1500).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
The acute oral toxicity was evaluated in a well conducted GLP and OECD guideline 401 study (limit study) with Sprague-Dawley Albino rats.10 rats (5 male rats and 5 female rats) were administrated at dose of 5000mg/kg bw/day. All animals survived. Signs seen on the day of dosing in a few animals included wet rales and soft stool. A few animals had decreased food consumption on the day of dosing; this continued in some animals through Day 2. One male had swollen nose on Days 3 and 4. All surviving animals were free of significant abnormalities from Day 3 through termination of the study. The LD50(rat) > 5000mg/kg bw/day was established in this study.(1995)
Acute dermal toxicity
The acute dermal toxicity was evaluated in a key study according to 16 CFR 1500 with albino new Zealand white rabbits. 10 rabbits (6 male rabbits and 4 female rabbits) were administrated at dose of 2000 mg/kg bw/day. Only one male rabbit died on day 4 of the study. Most animals were free of significant signs of systemic toxicity on the day of dosing. LD50(rabbit)>2000kg/kg bw/day was established in this study.(1995)
Justification for classification or non-classification
Based on the available information in the dossier, the substance Chiguard 380/Chiguard 380W (CAS# 18600-59-4) does not need to be classified for acute toxicity when considering the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC.
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