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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The oral LD50 was >5000 mg/kg bw in rats.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Oral toxicity

Single oral administration of dioctadecyl ether to 5 male and 5 female rats at a dose of 5000 mg/kg bw (in mineral oil by gavage), in a GLP compliant study in accordance with OECD guideline 401, did not cause any mortality or clinical signs during the observation period of 14 days (EVIC-CEBA, 1997). Furthermore, the weight growth of the animals was not affected and no gross lesions were visible at autopsy. As a result, the LD50 of dioctadecyl ether is >5000 mg/kg bw. Dermal toxicity

The study was performed with a close homolog (dioctylether) as a limit test according to OECD guideline 402. Wistar rats (5 males and 5 females) were randomly selected for the study. The group was exposed to a single dermal dose of 2000 mg/kg b.w. for 24 hours followed by an observation period of 14 days. During the study clinical signs of reaction to the treatment were recorded daily. Body weight was recorded once a week. After the two-week observation period the animals were killed and subjected to a gross necropsy examination.All animals survived the application and did not reveal any signs of toxicity. The animals gained the expected body weight. No skin reactions at the application site were observed. No macroscopic findings were observed at necropsy.These results indicate that the test substance has no significant toxic effect in the rat following dermal administration of a single dose at a level of 2000 mg/kg. 

Justification for classification or non-classification

Based on the results of the acute oral toxicity study, dioctadecyl ether does not need to be classified according to Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.