Registration Dossier
Registration Dossier
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EC number: 228-567-1 | CAS number: 6297-03-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No study is available in which the toxicokinetic properties (distribution, metabolism, elimination) of diocytlether were investigated.
Information about the dermal absorption behaviour was tested.
The expected toxicokinetic behaviour is derived from the physicochemical properties, the results from the available toxicological studies and the available literature following the information given in guidance document 7c.
Dioctadecylether having a molecular weight of ~523 g/mol is a solid with a water solubility of <1 mg/L (20°C) . It has a low volatility and a lipophilic character (log Pow >16). The structure shows no hydrolysable groups or ionic elements.
Oral and GI absorption:
Substance is not soluble in water and in GI fluids. It will not easily pass through aqueous pores or epithelial barriers. The substance may be taken up by micellular solubilisation. The limited systemic toxicity furthermore does not indicate an absorption through the GI tract.
Inhalative absorption:
Substance is not easily soluble in mucous and does not easily pass through aqueous pores or epithelial barriers. An absorption via the lung is therefore not assumed.
Dermal absorption:
Due to the physico chemical information, the substance can be assumed to be absorbed via the skin. A low transfer between the stratum corneum and the epidermis is assumed. Experimental data show that the penetration of the homolog dioctylether through the skin is below 1%. As a consequence the systemic availablity should be low after dermal exposure.
Distribution:
The molecular weight points to a wide distribution. On the other side due to the low solubility a bad distribution can be assumed. A distribution into fat cells is possible.
Accumulative potential:
Based on the PC information the main site of accumulation is assumed to be the adipose tissue as well as skin. The substance will be sloughed off with the skin. No accumulation in bone or in lung is predicted.
Metabolism:No detailed information can be derived concerning the metabolism.
Reactivity:Available studies on genotoxicity were negative, i. e. there is no indication of a reactivity of dioctadecylether or its metabolites under the test conditions.
Excretion:
Due to the physico chemical information an excretion of the substance via the urine is quesionable. An exalation is not assumed due to the low vapor pressure.
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