Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Principles of method if other than guideline:

None

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Type:

log Pow

Partition coefficient:

< -6.29

Temp.:

20 °C

Remarks on result:

other: no pH determined

Details on results:

According to this preliminary test the solubility of the test item in n-octanol is below 24.9 mg/l (without correction of the purity). With the data obtained from the experiments in chapter 3.5.1 (cs < 24.9 mg/l) and in the preliminary test (water solubility: cs = 208 to 1040 g/l) the partition coefficient was calculated as log Pow in the range of -3.9 to -4.6.
Due to the fact, that the log Pow is below -2, the partition coefficient n-octanol/water has to be estimated from the individual solubility in water and n-octanol.

By means of the flask method, the saturation concentration of the test item in n-octanol was determined to: < 0.243 mg/l.
By means of the flask method, the saturation concentration of the test item in water was determined to: 443 g/l

Conclusions:

The partition coefficient n-octanol/water of the test item at 20 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) <- 6.29

Executive summary:

The partition coefficient n-octanol/water of FAT 40210/F was determined according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). The partition coefficient at 20 °C, from the individual solubility in water and n-octanol, was determined to be (log Pow) <- 6.29.

Description of key information

The partition coefficient at 20 °C, calculated from the individual solubility in water and n-octanol, was determined to be (log Pow) <- 6.29.

Key value for chemical safety assessment

Log Kow (Log Pow):

-6.29

at the temperature of:

20 °C

Additional information

The partition coefficient n-octanol/water of FAT 40210/F was determined according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). The partition coefficient at 20 °C, from the individual solubilities in water and n-octanol, was determined to be (log Pow) <- 6.29.