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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The oral LD50 is between 100 and 200 mg/kg body weight (bw);  the inhalatory LC50 value is between 1000 and 2000 ppm; and the dermal LD50 is less than 500 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
100 mg/kg bw
Quality of whole database:
Adequate. The substance is corrosive, so duplication of in vivo testing shall be avoided, as stated in the Introduction to Annex VIII, Regulation EC No. 1907/2006.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
4 300.2 mg/m³ air
Quality of whole database:
Adequate. The substance is corrosive, so duplication of in vivo testing shall be avoided, as stated in the Introduction to Annex VIII, Regulation EC No. 1907/2006.

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
500 mg/kg bw
Quality of whole database:
Adequate. The substance is corrosive, so duplication of in vivo testing shall be avoided, as stated in the Introduction to Annex VIII, Regulation EC No. 1907/2006.

Additional information

Justification for selection of acute toxicity – oral endpoint
The oral LD50 in rats is between 100 and 200 mg/kg. This meets the criteria of CLP Acute Toxicity Category 3, where the LD50 is between 50 and 300 mg/kg in rats.

Justification for selection of acute toxicity – inhalation endpoint
The inhalatory LC50 in rats is between 1000 and 2000 ppm. This meets the criteria of CLP Acute Toxicity Category 3, where the LC50 is between 500 and 2500 ppm in rats. The value of 1000 ppm (molecular weight of 105.14) is equivalent to 4300 mg/m3. The LC50 is > 4300 mg/m3.

Justification for selection of acute toxicity – dermal endpoint
The dermal LD50 in guinea pigs is less than 500 mg/kg bw. The guinea pig is a fair surrogate for the rat in estimating acute dermal toxicity. Classification and labeling, and risk management measures, will be recommended to protect workers who handle this substance.

Justification for classification or non-classification

4-Vinylpyridine is classified, according to Regulation (EC) No. 1272/2008, as Acute Toxicity Category 3 for oral toxicity, as the LD50 between 100 and 200 mg/kg bw in the rat falls within the classification criteria of 50 to 300 mg/kg bw.  For acute dermal toxicity, 4-Vinylpyridine is classified as Acute Category 3, as the LD50 value of less than 500 mg/kg bw falls between 200 and 1000 mg/kg bw.  4-Vinylpyridine is classified as Acute Toxicity Category 3 for acute inhalation toxicity, as the LC50 between 1000 and 2000 ppm (> 4300 mg/m3) in the rat falls within the classification criteria of 500 to 2500 ppm. Due to its corrosive nature, it is also classified as H071, Corrosive to the respiratory tract. According to Directive 67/548/EEC, 4-vinylpyridine is classified as T, R23/24/25, (Toxic by inhalation, in contact with skin or if swallowed).