4-vinylpyridine

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This review of toxicokinetics is reliable as it accounts for all the relevant available data in the published and unpublished literature.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Materials and methods

Objective of study:

other: Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Studies and publications were provided to a qualified toxicologist who reviewed the relevant available information and provided an assessment of the likely toxicokinetic behaviour of the substance.

GLP compliance:

no

Remarks:

not required

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

IUPAC Name:

2-vinylpyridine

Test material form:

other: liquid

Radiolabelling:

no

Results and discussion

Preliminary studies:

2-Vinylpyridine (2VP) and 4-vinylpyridine (4VP) are considered read-across analogues based on structural similarity; they are isomers. This structural similarity results in their display of similar properties in physical and biological systems. 2VP and 4VP display characteristics of both pyridine and the vinyl group which comprises the constituent group. They display similar physico-chemical properties, environmental fate and ecotoxicity values, and similar toxicological properties. A review of the literature (as available) on 4VP concerning toxicokinetic parameters is not expected to result in different conclusions from that of 2VP.

Main ADME results

Main ADME results 1

Type:

absorption

Results:

Small molecular weight, high water solubility and low octanol/water partition coefficient indicate that the substance is likely to be absorbed in the GI tract and via the skin.

Main ADME results 2

Type:

distribution

Results:

Small molecular weight and high water solubility indicate that the substance is likely to be distributed in into the water compartment of the body. Skin sensitisation results suggest that the substance can bind to proteins in the blood.

Main ADME results 3

Type:

metabolism

Results:

Small molecular weight and lack of microbial biodegradation suggest that metabolism may not be necessary to allow excretion from the body.

Main ADME results 4

Type:

excretion

Results:

Excretion via the kidney is likely significant due to high water solubility and small molecular weight. Any substance which is not absorbed via the GI tract will be excreted in the faeces.

Metabolite characterisation studies

Metabolites identified:

no

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no bioaccumulation potential based on study results
Assessment of the toxicokinetic behaviour of 4VP was undertaken to the extent that can be derived from the relevant available information on a close structural analogue, 2-vinylpyridine. The two substances have very similar physico-chemical and toxicity behaviours and data betweent the two substances can be interchanged for regulatory purposes, such as classification and labeling, PBT and vPvB determination and risk assessment. Critical data include is small molecular weight, high water solubility and low octanol/water partitioning. These data suggest that 4VP is likely to be absorbed via the gastrointestinal tract, distributed in the water compartment of the body, and excreted via the kidneys with or without metabolism. Bioaccumulation and deposition in fat or breast milk is not likely.