2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl ethyl carbonate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-08-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 20131219 (China)
- Expiration date of the lot/batch: January 20, 2019

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature (20 °C ± 5 °C), under dark and dry conditions

Key result

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

Remarks on result:

other: The determination was performed above the melting range of the test item; this value however is expected to be overestimated, because it was determined from the molten material.

The weight loss below melting point was not significant and not reproducible. Under these conditions the vapour pressure cannot be determined with sufficient accuracy. The determination was done applying temperatures above the melting point. The regression curve for calibration is: The coefficient of correlation (r²) was 0.9981. Extrapolation of the curve to 20 °C and fitting this value in the regression curve, a vapour pressure of 1.46 × 10-9 Pa was obtained (temperature program 190 to 230 °C, evaluation at 200 to 230 °C)

Conclusions:

The vapour pressure of FAT 93503/B at 20 °C (293K) was 1.46E-9 Pa.

Executive summary:

The vapour pressure of FAT 93503/B was determined in a study conducted according to OECD Guideline 104 and EU A.4 Method. The isothermal thermogravimetrical effusion method was used for this purpose. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss. According to Sponsor information (Report Determination of the melting point) the test item FAT 93503/B melted at 175 °C. Below the melting point of the test item no significant weight loss was observed or the weight loss was not reproducible. In this temperature range the vapour pressure cannot be determined with sufficient accuracy. A value of the vapour pressure of the test item could only be determined using the data obtained above the melting point. The vapour pressure of the test item at 20 °C (293K) was calculated to be 1.46 × 10^-9 Pa (mean of three determinations).

Description of key information

The vapour pressure of FAT 93503/B was determined in a study conducted according to OECD Guideline 104 and EU A.4 Method. The isothermal thermogravimetrical effusion method was used for this purpose. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss. According to Sponsor information (Report Determination of the melting point) the test item FAT 93503/B melted at 175 °C. Below the melting point of the test item no significant weight loss was observed or the weight loss was not reproducible. In this temperature range the vapour pressure cannot be determined with sufficient accuracy. A value of the vapour pressure of the test item could only be determined using the data obtained above the melting point. The vapour pressure of the test item at 20 °C (293K) was calculated to be 1.46 × 10^-9 Pa (mean of three determinations).

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C