Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-133-9 | CAS number: 56641-05-5 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data on the read-across substance 2-phenoxyethyl acrylate demonstrate a low acute oral and dermal toxicity.
See attached read-across justification in section 13.
No inhalation study is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- two doses were used
- Principles of method if other than guideline:
- acute toxicity study with one oral exposure, dose levels at 2150 and 5000 mg/kg.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 males and 5 females per concentration, approximately 12 weeks at start. At least one week acclimatization.
Food; SSNIFF R; FA.SSNIFF, Versuchstierdiaeten; 4470 Soest - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- other: At highest dose, 5000 mg/kg bw; Dyspnea, staggering and overall bad condition were observed after one hour and untill 2 days. Shaggy fur was observed between 1 and 13 days. Apathy, anormalous behavior, signs of pain, spastic walking, redness of skin, dry
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
- Conclusions:
- No mortality were observed in any of the two doses tested. The acute LD50 value is therefore above 5000 mg/kg
- Executive summary:
The acute toxicity of phenoxyethyl acrylate was tested in a single dose acute toxicity test, comparable to OECD Guideline 401. Two doses were tested 2150 and 5000 mg/kg. The substance was giving orally dissolved in olive oil, total volume was 5 and 10 ml/kg bw, which is acceptable according to the OECD guideline. Several clinical signs were observed, such as dyspnoea, shaggering, shaggy fur, redness of skin and hemi paralysis. The symptoms gradually ceased within hours to two days, except shaggy fur in the highest dose. No mortality was observed at any of the doses, therefore the acute LD50 value is above 5000 mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Data on target substance not available. Thus, read-across has been applied using data from the source substance 2-phenoxyethyl acrylate (S1).
See further read-acoss justification in attached document to section 13. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: data on read-across substance
- Executive summary:
No data is available for Phenol, ethoxylated, esters with acrylic acid (T).
From acute oral toxicity testing of 2 -phenoxyethyl acrylate in accordance with OECD 401 no mortality was observed for male/female rats at the highest tested dose 5000 mg/kg bw, thus LD50>5000 mg/kg bw. Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, a LD50 >5000 mg/kg bw can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well.
See justification for read-across attached in section 13.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to the relevant guideline under GLP conditions, inclusive certificate
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female rats obtained from Harlan Olac Ltd, Bicester Oxon, England.
Rats were housed individually in metal cages with wiremesh floor. Standard rodent diet and water were provided ad libitum.
Temperature was 21C, relative humidity was 50-51%, and 12:12 light:dark period. - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Five males and five females were treated. The day before treatment, the hair was removed from the dorso-lumbar region, approximately 10% of bodysurface (5*5 cm). The test substance was applied, by spreading it evenly, and then covered by gauze, and kept in place with a non-irritative dressing, encircled firmly around the trunk.
- Duration of exposure:
- 14 days
- Doses:
- 2.0 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed during the experiment
- Clinical signs:
- other: No signs of systemic reactions to treatment
- Gross pathology:
- No macroscopic abnormalities onserved at day 15
- Other findings:
- Slight or well-defined erythema was observed at the site of application, for two male and three female rats on day 2. No other dermal changes and irritation has resolved at day 3.
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance can not be considered acutely toxic via the dermal route.
- Executive summary:
Rats of both sexes were given 2 g/kg as a single dermal exposure and followed 14 days after exposure.
No mortality was observed . I addition no clinical signs nor macroscopic abnormalities were observed. A slight or well defined erythema was observed at the site of application for 2 and 3 male and females rats on day 2, respectively. No other dermal changes was observed, and irritation had resolved at day 3.
The substance can not be considered acutely toxic via the dermal route.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Data on target substance not available. Thus, read-across has been applied using data from source substances 2-phenoxyethyl acrylate (S1).
See further read-acoss justification in attached document to section 13. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: data on read-across substance
- Executive summary:
No data is available for Phenol, ethoxylated, esters with acrylic acid (M142) (T).
The acute dermal toxicity of 2-phenoxyethyl acrylate was tested in female and male rats with 2 g/kg as a single dermal exposure and followed 14 days after exposure. The test was performed in accordance with EU Method B.3. No mortality, clinical signs or abnormalities were observed. A slight or well defined erythema was observed at the site of application for 2 and 3 male and females rats on day 2, respectively. No other dermal changes was observed, and irritation had resolved at day 3 (72hours). Thus, the substance can not be considered acutely toxic via the dermal route. Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, no acute dermal toxicity be concluded for Phenol, ethoxylated, esters with acrylic acid as well.
See justification for read-across attached in section 13.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
The available studies on acute toxicity of 2-phenoxyethyl acrylate show that the substance has low acute toxicity. No mortality was observed in the studies available (oral and dermal). In the oral toxicity study using single dose levels of 2150 and 5000 mg/kg, several clinical signs of toxicity were observed including dyspnoea, shaggering, shaggy fur, redness of skin and hemi paralysis. The symptoms gradually ceased within hours to two days except for the highest dose level. In the dermal toxicity study, rats were given 2000 mg/kg as a single dermal exposure. Neither clinical signs nor macroscopic abnormalities were observed. A slight or well defined erythema was observed at the site of application on day 2. No other dermal changes were observed and irritation had resolved at day 3.
Overall, 2-phenoxyethyl acrylate demonstrates a low acute oral and dermal toxicity. No inhalation study is available.
Justification for selection of acute toxicity – oral endpoint
The study is an OECD Guideline 401 study
Justification for selection of acute toxicity – inhalation endpoint
No inhaltion study available. Annex VIII requirement for second
exposure route is fulfilled as both an acute oral and an acute dermal
expossure study is availabe.
Justification for selection of acute toxicity – dermal endpoint
The study was performed according to EU Method B 3, under GLP
conditions
Justification for classification or non-classification
The available data on acute toxicity suggest that the read-across substance 2 -phenoxyethyl acrylate and hence also the target substance Phenol, ethoxylated, esters wit acrylid acid
should not be classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.