Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-133-9 | CAS number: 56641-05-5 1 - 2.5 moles ethoxylated
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
As no specific data for the absorption rate from the oral, the dermal or the inhalational route of exposure is available, default assumptions will be applied. Thus, absorption from the dermal and the oral route is considered to be the same. For extrapolation from oral exposure to inhalation exposure the absorption by inhalation is assumed to be a factor 2 higher.
Wistar Han rats were treated with Phenol, ethoxylated, esters with acrylic acid by daily oral gavage at dose levels of 100, 300 and 1000 mg/kg/day in accordance with OECD 422. Based on the results of this combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test, the no-observed-adverse-effect levels (NOAEL) for parental toxicity was evaluated to be 300 mg/kg/day based on histopathological forestomach lesions in both sexes at 1000 mg/kg/day. No treatment-related changes were noted in any of the other parameters investigated in this study (i.e. clinical appearance, functional observations (motor activity, grip strength, hearing ability, pupillary reflex and static righting reflex), food consumption, clotting parameters and male T4 thyroid hormone levels). Based on the available findings from the OECD 422 study with Phenol, ethoxylated, esters with acrylic acid, no severe adverse systemic toxicity was observed and no classification is proposed for repeated dose toxicity (STOT RE classification according to EC 1272/2008).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Based on available data from an OECD 422 study, a low bioaccumulation potential of phenol, ethoxyklated, esters with acrylic acid is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
