Phenol, ethoxylated, esters with acrylic acid

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The experimental result is a standard 48 hour toxicity test, with a standard test species, and according to a German Guideline that is similar to OECD Guideline 202.However no information on GLP is provided.

Qualifier:

according to guideline

Guideline:

other: EG-Richtlinie 79/831/EWG, Anhang V, Teil C: Methoden zur bestimmung der ökotoxizität für daphniden

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

not specified

Details on sampling:

Mobility of the test species was determined at 3,6,24 and 48 hours

Details on test solutions:

0.0195-10 mg/l
pH; 7.7-8.3

Test organisms (species):

Daphnia magna

Details on test organisms:

Daphnia magna straus was obtained from Institute National de Recherche Chimique Appliquee, France. The strain has been in the BASF laboratory since 1978.

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Hardness:

2.7 +/- 0.5 mmol/l

Test temperature:

19-21C (292.0-294.0 Kelvin)

pH:

7.7-8.3

Nominal and measured concentrations:

Nominal concentrations were from 0.0195 to 10 mg/l

Reference substance (positive control):

no

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

3.85 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 3.83-3.88

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.21 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 0.94-1.58

Validity criteria fulfilled:

yes

Conclusions:

EC50 values for phenoxyethyl acrylate was established to 3.85 and 1.21 mg/l, for 24 and 48 hours, respectively.

Executive summary:

EC50 values for phenoxyethyl acrylate on Daphnia magna were established according to a German guideline similar to OECD Guideline 202. Immobilization was reported at time 0,3,6,24 and 48 hours, and EC50 values were established to 3.55 and 1.21 mg/l at 24 and 48 hours, respectively.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read-across to study with high reliability (2)

Justification for type of information:

Data on target substance not available. Thus, read-across has been applied using data from source substances (S1).
See further read-acoss justification in attached document to section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

24

Dose descriptor:

EC50

Effect conc.:

3.85 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 3.83-3.88

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.21 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Conclusions:

No data is available for Phenol, ethoxylated, esters with acrylic acid (M142) (T).
The short-term toxicity of 2-phenoxyethyl acrylate to Daphnia Magna was tested according to a German guideline similar to OECD Guideline 202. Immobilization was reported at time 0, 3, 6, 24 and 48 hours, and EC50 values were established to 3.55 and 1.21 mg/L at 24 and 48 hours, respectively.
Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, a 24h EC50 of 3.55 mg/L, and a 48h EC50 of 1.21 mg/L can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well.

Executive summary:

No data is available for Phenol, ethoxylated, esters with acrylic acid (M142) (T).

 

The short-term toxicity of 2-phenoxyethyl acrylate to Daphnia Magna was tested according to a German guideline similar to OECD Guideline 202. Immobilization was reported at time 0, 3, 6, 24 and 48 hours, and EC50 values were established to 3.55 and 1.21 mg/L at 24 and 48 hours, respectively.

Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, a 24h EC50 of 3.55 mg/L, and a 48h EC50 of 1.21 mg/L can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well.

 

See justification for read-across attached in section 13.

Description of key information

A Daphnia immobilization test was identified, the test is conducted similar to OECD Guideline 202. EC50 was established to 1.21 mg/l (48h)
No data for marine invertebrates have been identified

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.21 mg/L

Additional information

EC50 values for phenoxyethyl acrylate on Daphnia magna were established according to a German guideline similar to OECD Guideline 202. Immobilization was reported at time 0,3,6,24 and 48 hours, and EC50 values were established to 3.55 and 1.21 mg/l at 24 and 48 hours, respectively.

Due to structural and pysico-chemical similarity to Phenol, ethoxylated, esters with acrylic acid, a 24h EC50 of 3.55 mg/L, and a 48h EC50 of 1.21 mg/L can also be concluded for Phenol, ethoxylated, esters with acrylic acid as well.